Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relationship between coronary function by positron emission tomography andtemporal changes in morphology by intravascular ultrasound (IVUS) in transplant recipients
Autore:
Allen-Auerbach, M; Schoder, H; Johnson, J; Kofoed, K; Einhorn, K; Phelps, ME; Kobashigawa, J; Czernin, J;
Indirizzi:
Univagingf Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Ahmanson Biol Im Univ Calif Los Angeles Los Angeles CA USA 90095 armacol, Ahmanson Biol Im
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 3, volume: 18, anno: 1999,
pagine: 211 - 219
SICI:
1053-2498(199903)18:3<211:RBCFBP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; ORTHOTOPIC HEART-TRANSPLANTATION; CARDIAC ALLOGRAFT VASCULOPATHY; ARTERY DISEASE; ENDOTHELIAL DYSFUNCTION; INTRACORONARY ULTRASOUND; N-13 AMMONIA; VASODILATION; RESERVE; QUANTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Czernin, J Univagingf Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Ahmanson Biol Im Univ Calif Los Angeles AR-259 CHS Los Angeles CA USA 90095 l Im
Citazione:
M. Allen-Auerbach et al., "Relationship between coronary function by positron emission tomography andtemporal changes in morphology by intravascular ultrasound (IVUS) in transplant recipients", J HEART LUN, 18(3), 1999, pp. 211-219

Abstract

Background: Transplant coronary vasculopathy is one of the major causes ofgraft failure and death in cardiac transplant recipients. A non-invasive test of coronary function to predict the course of this disease would be desirable. Methods: To determine whether the degree of abnormalities in endothelial dependent coronary vasomotion (cold presser testing) or endothelial independent vasodilatory capacity (intravenous dipyridamole) as determined by positron emission tomography (PET) one to two years after heart transplantation is correlated with the course of transplant vasculopathy. Nineteen patientshad baseline PET and intravascular ultrasound studies (IVUS) at 18 +/- 6 months after cardiac transplantation and a follow up IVUS study 15 +/- 5 months later. Results: Myocardial blood flow was higher in patients than in healthy controls (p < 0.002) but increased during cold presser testing only in controls(p < 0.005). Myocardial blood flow normalized to the rate pressure productdeclined in patients (p < 0.001). Dipyridamole-induced hyperemic blood flow and the flow reserve normalized to the resting rate pressure product werelower in patients than in controls (p < 0.001 and p < 0.01). The normalized flow reserve was correlated with changes in total vessel area (r = 0.55; p = 0.02) and lumen diameter (r = 0.52; p < 0.05). Conclusion: These findings suggest that the degree of abnormalities in endothelial independent myocardial flow as detected by PET one to two years after transplantation is associated with morphological indices of disease progression by IVUS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:16:04