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Titolo:
Human papillomavirus and the development of non-melanoma skin cancer
Autore:
Harwood, CA; McGregor, JM; Proby, CM; Breuer, J;
Indirizzi:
Royal Hosp, NHS Trust, Dept Virol, London E1, England Royal Hosp London England E1 , NHS Trust, Dept Virol, London E1, England Royal Hosp, NHS Trust, Dept Acad Dermatol, London E1, England Royal Hosp London England E1 ust, Dept Acad Dermatol, London E1, England
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 4, volume: 52, anno: 1999,
pagine: 249 - 253
SICI:
0021-9746(199904)52:4<249:HPATDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-TRANSPLANT RECIPIENTS; SQUAMOUS-CELL CARCINOMAS; EPIDERMODYSPLASIA-VERRUCIFORMIS; ALLOGRAFT RECIPIENTS; P53 GENE; PUVA; PSORALEN; DNA; RISK; IMMUNOSUPPRESSION;
Keywords:
human papillomavirus; non-melanoma skin cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Breuer, J Sttfieldolomews & Royal London Sch Med & Dent, Univ London QueenMary & Wes St Bartholomews & Royal London Sch Med & Dent 37 Ashfield St London England E1 1BB
Citazione:
C.A. Harwood et al., "Human papillomavirus and the development of non-melanoma skin cancer", J CLIN PATH, 52(4), 1999, pp. 249-253

Abstract

Human papillomaviruses (HPV) are increasingly recognised as important human carcinogens. The best established association with human malignancy is that of high-risk mucosal HPV types and anogenital cancer. HPV-induced transformation of anogenital epithelia has been the subject of intense research which has identified the cellular tumour suppressor gene products, p53 and pRB, as important targets for the viral oncoproteins E6 and E7 respectively. Certain HPV types are also strongly associated with the development of non-melanoma skin cancer in the inherited disorder epidermodysplasia verruciformis (EV). However, in contrast with anogenital malignancy the oncogenic mechanisms of EV-HPV types remain uncertain, and there appears to be a crucial additional requirement for ultraviolet radiation. Cutaneous HPV types in the general population are predominantly associated with benign viral warts, but a role in non-melanoma skin cancer has recently been postulated. Polymerase chain reaction based HPV detection techniques have shown a high prevalence of HPV DNA, particularly in skin cancers from immunosuppressed patients and to a lesser extent in malignancies from otherwise immunocompetent individuals. No particular HPV type has yet emerged as predominant, and the role of HPV in cutaneous malignancy is unclear at present. It remains to beestablished whether HPV plays an active or purely a passenger role in the evolution of non-melanoma skin cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:53:40