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Titolo:
Role of Fourier transform infrared spectroscopy in the rehearsal phase of combinatorial chemistry: a thin-layer chromatography equivalent for on-support monitoring of solid-phase organic synthesis
Autore:
Yan, B; Gremlich, HU;
Indirizzi:
Novartis Pharmaceut Corp, Dept Core Technol, Summit, NJ 07901 USA NovartisPharmaceut Corp Summit NJ USA 07901 echnol, Summit, NJ 07901 USA Novartis Pharma AG, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 725, anno: 1999,
pagine: 91 - 102
SICI:
1387-2273(19990402)725:1<91:ROFTIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAD FTIR MICROSPECTROSCOPY; PROTECTING GROUPS; PEPTIDE-SYNTHESIS; POLYMER SUPPORTS; RESIN SUPPORTS; IR; LIBRARIES; DISCOVERY; TOOLS;
Keywords:
reviews; organic synthesis; Fourier transform infrared spectroscopy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Yan, B Novartis01harmaceut Corp, Dept Core Technol, 556 Morris Ave, Summit, NJ 079 Novartis Pharmaceut Corp 556 Morris Ave Summit NJ USA 07901 NJ 079
Citazione:
B. Yan e H.U. Gremlich, "Role of Fourier transform infrared spectroscopy in the rehearsal phase of combinatorial chemistry: a thin-layer chromatography equivalent for on-support monitoring of solid-phase organic synthesis", J CHROMAT B, 725(1), 1999, pp. 91-102

Abstract

The adaptation of diverse organic reactions to solid supports requires significant reaction optimization efforts. A convenient on-support analytical method functionally similar to TLC in solution chemistry is very advantageous. As a TLC-equivalent method, the single bead FTIR is a simple, sensitive, fast, and convenient analytical method to monitor SPOS without stopping the reaction or cleaving the product. As with TLC, single bead FTIR providesa wide range of information such as qualitative assessment, quantitative determination, and reaction kinetics. Studies with the single bead FTIR havenot only provided a tool for daily monitoring of the solid-phase reactions, but a way to understand the properties of polymer-bound substrate and thenature of polymer-supported organic reactions. It has assisted in the selection of a wide range of reaction conditions rapidly for SPOS in the rehearsal phase of combinatorial chemistry. Due to its convenience and efficiencyFTIR internal reflection spectroscopy has evolved as a useful analytical methodology for monitoring of combinatorial chemistry reactions directly on polymer surface. (C) 1999 Elsevier Science B.V All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:58:19