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Titolo:
Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: Heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma
Autore:
Ree, HJ; Kadin, ME; Kikuchi, M; Ko, YH; Suzumiya, J; Go, JH;
Indirizzi:
SamsungaMed Ctr, Dept Diagnost Pathol, Kangnam Gu, Seoul 135710, South Kore Samsung Med Ctr Seoul South Korea 135710 am Gu, Seoul 135710, South Kore Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA USA Harvard Univ Boston MA USA Beth Israel Deaconess Med Ctr, Boston, MA USA Fukuoka Univ, Sch Med, Fukuoka 81401, Japan Fukuoka Univ Fukuoka Japan 81401 oka Univ, Sch Med, Fukuoka 81401, Japan Sung Kyun Kwan Univ, Coll Med, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea niv, Coll Med, Seoul, South Korea
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 4, volume: 30, anno: 1999,
pagine: 403 - 411
SICI:
0046-8177(199904)30:4<403:BEIRFH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTER B-CELLS; PREDOMINANCE HODGKINS-DISEASE; PROTEIN; GENE;
Keywords:
angioimmunoblastic T-cell lymphoma; AILD; germinal center; Bcl-6; CD57; intrafollicular T-cells; HIV-adenopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ree, HJ Samsung710, Ctr, Dept Diagnost Pathol, Kangnam Gu, 50 Ilwon Dong, Seoul 135 Samsung Med Ctr 50 Ilwon Dong Seoul South Korea 135710 Seoul 135
Citazione:
H.J. Ree et al., "Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: Heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma", HUMAN PATH, 30(4), 1999, pp. 403-411

Abstract

Background: The Bcl-6 gene product, a nuclear phosphoprotein, is expressedindependently of Bcl-6 gene rearrangement. In lymph nodes, expression of Bcl-6 protein is restricted to germinal center (GC) B-cells and 10% to 15% of CD3/CD4(+) intrafollicular T cells. Interfollicular cells are negative for Bcl-6 protein, except for rare CD3(+)/CD4(+) T cells. Recently, we reported cases of angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs(AITL/GC), and observed that borders of enlarged GCs were ill defined, with features suggestive of an outward migration of GC cells to surrounding interfollicular zones. This prompted a study of follicular borders with Bcl-6staining in reactive follicular hyperplasias and follicular lymphomas to compare with AITL/GC. Materials and Methods: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6. Six cases of AITL/GC, 12 nonspecific reactive follicular hyperplasia (FH), 7 HIV adenopathy, 10 follicular lymphoma (FL), and 8 typical AITL (ie, AITL without GC) were studied. Double staining for Bcl-6/CD20, Bcl-6/CD3, and Bcl-6/CD57 was performed in selected cases. Results: In FH and HIV adenopathy, staining for Bcl-6 revealed densely populated GCs with well-defined and regular GC borders, whereas Bcl-6() cells were rare in the interfollicular areas. An occasional GC with an ill-defined border was invariably surrounded by a broad mantle zone; those with indistinct mantle zones had well defined, regular borders. In FL, follicles were densely populated, and their borders were irregular, with some Bcl-6(+) cell in the interfollicular zones. In AITL/GC, GCs were less dense, GC borders were ill defined and irregular, and the number of interfollicular Bcl-6(+) cells was markedly increased. Double staining revealed that these interfollicular Bcl-6(+) cells in AITL/GC were Bcl-6(+)/CD3(+)/CD20(-)/CD57(-) T cells. Moreover, CD3(+) intrafollicular T cells were depleted in AITL/GC, whereas they were abundant in FH. Intrafollicular CD57(+) cells did not stain for Bcl-6, and were also depleted in AITL/GC. fn typical AITL, some neoplastic cells were positive for Bcl-6, showing variable degrees of staining Conclusions: (1) GCs of AITL/GC differed from those of other reactive follicular hyperplasias and follicular lymphomas, and staining for Bcl-6 was useful to discern them. (2) Intrafollicular CD3(+) T cells, many of which were also positive for Bcl-6, were markedly depleted in AITL/GC, with increased interfollicular Bcl-6(+)/ CD3(+) cells, suggesting an outward migration of intrafollicular T cells in this Condition. (3) Interfollicular Bcl-6(+)/CD3(+) cells in AITL/GC were too numerous to be accounted for by migration alone, suggesting local proliferation. (4) Intrafollicular CD57(+) cells were negative for Bcl-6 indicating heterogeneity of the intrafollicular T-cell. population. (5) Some neoplastic cells in AITL stained for Bcl-6, suggesting up-regulation of Bcl-6 expression in this: tumor. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:06:02