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Titolo:
Comparison of PCB congeners and pesticide levels between serum and milk from lactating women
Autore:
Greizerstein, HB; Stinson, C; Mendola, P; Buck, GM; Kostyniak, PJ; Vena, JE;
Indirizzi:
SUNY Buffalo, Toxicol Res Ctr, Buffalo, NY 14214 USA SUNY Buffalo BuffaloNY USA 14214 Toxicol Res Ctr, Buffalo, NY 14214 USA SUNY Buffalo, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 rmacol & Toxicol, Buffalo, NY 14214 USA SUNY Buffalo, Dept Clin Lab Sci, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 ept Clin Lab Sci, Buffalo, NY 14214 USA SUNY Buffalo, Dept Prevent & Social Med, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 ent & Social Med, Buffalo, NY 14214 USA
Titolo Testata:
ENVIRONMENTAL RESEARCH
fascicolo: 3, volume: 80, anno: 1999,
pagine: 280 - 286
SICI:
0013-9351(199904)80:3<280:COPCAP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS; ADIPOSE-TISSUE; ORGANOCHLORINE PESTICIDES; COPLANAR PCBS; BLOOD-LEVELS; BREAST-MILK; EXPOSURE; DIOXINS; PCDDS; PCDFS;
Keywords:
lactating women; PCBs; pesticides; serum; milk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Greizerstein, HB SUNY Buffalo, Toxicol Res Ctr, 111 Farber Hall, Buffalo, NY 14214 USA SUNY Buffalo 111 Farber Hall Buffalo NY USA 14214 214 USA
Citazione:
H.B. Greizerstein et al., "Comparison of PCB congeners and pesticide levels between serum and milk from lactating women", ENVIR RES, 80(3), 1999, pp. 280-286

Abstract

Samples of blood and milk were obtained from lactating women participatingin the New York State Angler study. A total of seven women gave one blood and one milk sample at time intervals between blood and milk collection different for each woman. The time between samples varied from 3 to 318 days. One subject provided a second milk sample 219 days after the first milk sample, The samples were analyzed for 69 PCB congeners, DDE (a metabolite of DDT), Mirex, and hexachlorobenzene (HCB), Lipid content was determined by gravimetric analysis. The congener profiles in serum and milk were similar for each individual but different among all subjects. The sum of the concentrations of the congeners present above the limit of detection was used to estimate the total PCB concentration that was in the range of 2.6 to 5.8 ng/gof serum and 3.5 to 14.1 ng/g of milk. The ratio of serum to milk concentrations varied from 0.18 to 1.66 with a mean of 0.65+/-0.49 showing no consistency among individuals prior to adjusting the data for lipid content. Thetotal PCB levels normalized for lipid content were 320 728 ng/g of serum lipid and 239 428 ng/g of milk lipid. The range of the lipid adjusted serum/milk ratio was 1.1 to 2.8 and the mean+/-SD serum/milk ratio was 1.9+/-0.5,The ranges of lipid adjusted serum concentration of DDE, HCB, and Mirex were 95 to 591, 8 to 48, and 3 to 29 ng/g lipid, respectively, The ranges of lipid adjusted milk concentration of DDE, HCB, and Mirex were 90 to 577, 11to 22, and 1 to 10 ng/g lipid, respectively. For DDE, HCB, and Mirex, the means of the individual lipid adjusted serum to milk ratios were 1.5+/-0.7 2.5+/-1.5, and 5.3+/-4.6, respectively. Considerable differences were foundamong lipid adjusted concentrations of these environmental pollutants in serum and milk samples from the same individual. This suggests that body burden estimates in lactating women using different matrices may not be equivalent even when lipid adjusted values are used. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:56:46