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Titolo:
Usefulness of the cytomegalovirus (CMV) antigenemia assay for predicting the occurrence of CMV disease and death in patients with AIDS
Autore:
Chevret, S; Scieux, C; Garrait, V; Dahel, L; Morinet, F; Modai, J; Decazes, JM; Molina, JM;
Indirizzi:
Hop St Louis, Serv Malad Infect, Dept Biostat, F-75010 Paris, France Hop St Louis Paris France F-75010 t, Dept Biostat, F-75010 Paris, France Hop St Louis, Dept Virol, F-75010 Paris, France Hop St Louis Paris France F-75010 uis, Dept Virol, F-75010 Paris, France Hop St Louis, Dept Infect Dis, F-75010 Paris, France Hop St Louis Paris France F-75010 Dept Infect Dis, F-75010 Paris, France
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 4, volume: 28, anno: 1999,
pagine: 758 - 763
SICI:
1058-4838(199904)28:4<758:UOTC(A>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; HIV-INFECTED PATIENTS; BLOOD LEUKOCYTES; DNA LOAD; DIAGNOSIS; VIREMIA; PLASMA; TRANSPLANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Molina, JM Hop010 Louis, Serv Malad Infect, Dept Biostat, 1 Ave Claude Vellefaux, F-75 Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 F-75
Citazione:
S. Chevret et al., "Usefulness of the cytomegalovirus (CMV) antigenemia assay for predicting the occurrence of CMV disease and death in patients with AIDS", CLIN INF D, 28(4), 1999, pp. 758-763

Abstract

A cohort study of 214 human immunodeficiency virus (HIV)-infected patientswas performed to assess the usefulness of the cytomegalovirus (CMV) antigenemia assay for predicting the occurrence of CMV disease and death. Multivariate analysis revealed that only positive baseline CMV antigenemia assays (relative risk [RR], 7.2; 95% confidence interval [CI], 3.7-14.2; P = .0001) and CD4 cell counts (RR, 0.98; 95% CI, 0.97-0.99; P = .009) were associated with CMV disease. A positive baseline CMV antigenemia assay was also associated with death by multivariate analysis (RR, 2.2; 95% CI, 1.5-3.4; P = .0003). Increasing levels of CMV antigenemia during follow-up were associated with increased risks of CMV disease and death. A positive CMV antigenemia assay that shelved >10 cells per 2 x 10(5) polymorphonuclear leukocytes during follow-up was 91% sensitive and 84% specific for predicting a diagnosis of CMV disease: the negative predictive value for this positive test washigh (97%). Therefore, the CMV antigenemia assay appears to be a simple, rapid, and inexpensive test for predicting the occurrence of CMV disease anddeath in patients with advanced HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:24:28