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Titolo:
Effects of doxazosin on hemorheological, hemodynamic and lipid parameters in patients with essential hypertension
Autore:
Toth, K; Nemes, J; Czopf, L; Kapronczay, P; Kesmarky, G; Juricskay, I;
Indirizzi:
Univ Pecs, Sch Med, Dept Med 1, Div Cardiol, H-7643 Pecs, Hungary Univ Pecs Pecs Hungary H-7643 t Med 1, Div Cardiol, H-7643 Pecs, Hungary Univ Pecs, Sch Med, Dept Med 1, Div Endocrinol, H-7643 Pecs, Hungary Univ Pecs Pecs Hungary H-7643 ed 1, Div Endocrinol, H-7643 Pecs, Hungary
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 1, volume: 20, anno: 1999,
pagine: 57 - 61
SICI:
1386-0291(1999)20:1<57:EODOHH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; WHOLE-BLOOD VISCOSITY; PLASMA VISCOSITY; RISK FACTOR; FIBRINOGEN; DEFORMABILITY; HEMATOCRIT; SPEEDWELL; PRESSURE; DRUGS;
Keywords:
essential hypertension; blood rheology; plasma lipids; doxazosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Toth, K Univarycs, Sch Med, Dept Med 1, Div Cardiol, Ifjusag U13, H-7643 Pecs, Hung Univ Pecs Ifjusag U13 Pecs Hungary H-7643 U13, H-7643 Pecs, Hung
Citazione:
K. Toth et al., "Effects of doxazosin on hemorheological, hemodynamic and lipid parameters in patients with essential hypertension", CL HEMORH M, 20(1), 1999, pp. 57-61

Abstract

It is known from previous studies that hemorheological parameters are altered in patients with essential hypertension. The hemorheological and hemodynamical effects of doxazosin, a selective alpha-1-adrenoreceptor blocker agent, was examined in twenty patients (mean age: 54 +/- 10 years) with essential hypertension. Hemorheologic (hematocrit, fibrinogen, plasma and whole blood viscosity) and hemodynamic (cardiac output and index, total peripheral resistance) parameters and plasma lipids were determined. The measurements were carried out before the beginning of the treatment, after 1 week and after 12 weeks treatment periods. Besides significant reduction of blood pressure and total peripheral resistance (p < 0.001), a decrease in cholesterol (p < 0.001) and triglyceride (p < 0.01) levels and a beneficial effect on hemorheological parameters was detected. Fibrinogen and plasma viscosity decreased significantly (p < 0.01). Hematocrit value was also lower after one week (p < 0.001), then an increase could be seen. Whole blood viscosity showed similar changes as hematocrit, but the degree of its final increase was slighter, which was supported by the significantly lower value of corrected blood viscosity (p < 0.05).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 07:39:46