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Titolo:
Effects of zolmitriptan (Zomig (TM)) on central serotonergic neurotransmission as assessed by active oddball auditory event-related potentials in volunteers without migraine
Autore:
Hughes, AM; Dixon, R; Dane, A; Kemp, J; Cummings, L; Yates, RA;
Indirizzi:
Zeneca Pharmaceut, Med Expt, Macclesfield SK10 4TG, Cheshire, England Zeneca Pharmaceut Macclesfield Cheshire England SK10 4TG heshire, England
Titolo Testata:
CEPHALALGIA
fascicolo: 2, volume: 19, anno: 1999,
pagine: 100 - 106
SICI:
0333-1024(199903)19:2<100:EOZ((O>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSITY DEPENDENCE; EVOKED-POTENTIALS; HEALTHY-VOLUNTEERS; 5HT(1B/1D) AGONIST; 311C90; P300; PHARMACOKINETICS; SYSTEM; MARKER; CAT;
Keywords:
cortical auditory evoked potential; humans; serotonin; zolmitriptan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hughes, AM ZenecaEnglandceut, Med Expt, Alderley Pk, Macclesfield SK10 4TG, Cheshire, Zeneca Pharmaceut Alderley Pk Macclesfield Cheshire England SK10 4TG
Citazione:
A.M. Hughes et al., "Effects of zolmitriptan (Zomig (TM)) on central serotonergic neurotransmission as assessed by active oddball auditory event-related potentials in volunteers without migraine", CEPHALALGIA, 19(2), 1999, pp. 100-106

Abstract

In this randomized, double-blind, three-period crossover trial, 24 healthyvolunteers without migraine received zolmitriptan 5 mg, dexfenfluramine 15mg or placebo orally. At 2, 6, and 24 h postdose, auditory stimuli of 1000Hz (nontarget tone) and 2000 Hz (target tone) were randomly and binaurallypresented in an active oddball paradigm (4:1 ratio). Cortical auditory evoked responses were recorded for 500 msec poststimulus. Plasma concentrations of zolmitriptan and a 17-lead quantitative EEG were assessed at the same timepoints. Relative to placebo, zolmitriptan reduced the maximum absolute amplitude, amplitude difference (from nontarget tone noise) and area under the curve of the cortical auditory target tone event-related potential (P300 ERP). The most dramatic effect of zolmitriptan was to diminish the point estimate of noise during the 200-400 msec poststimulus epoch. The effect ofzolmitriptan appeared concentration dependent. The latency of the P300 ERPwas unaffected by zolmitriptan and there was no clinically significant effect on the EEG. Modification by zolmitriptan of the cortical electrical activity evoked by auditory stimuli confirms a central action of this drug in humans, which appears to affect cortical information processing without global alteration of the quantitative EEG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:27:33