Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Impact of the expression of cyclin-dependent kinase inhibitor p27(Kip1) and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma
Autore:
Ohtani, M; Isozaki, H; Fujii, K; Nomura, E; Niki, M; Mabuchi, H; Nishiguchi, K; Toyoda, M; Ishibashi, T; Tanigawa, N;
Indirizzi:
Osakapand Coll, Dept Gen & Gastroenterol Surg, Takatsuki, Osaka 5698686, Ja Osaka Med Coll Takatsuki Osaka Japan 5698686 Takatsuki, Osaka 5698686, Ja
Titolo Testata:
CANCER
fascicolo: 8, volume: 85, anno: 1999,
pagine: 1711 - 1718
SICI:
0008-543X(19990415)85:8<1711:IOTEOC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEASOME PATHWAY; PROGNOSTIC FACTORS; CANCER PATIENTS; CDK INHIBITORS; BREAST-CANCER; P27; PROTEIN; P21(WAF1/CIP1); RECURRENCE; P57(KIP2);
Keywords:
p27(Kip1) expression; apoptosis; prognosis; gastric carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigawa, N Osaka,Med Coll, Dept Gen & Gastroenterol Surg, 2-7 Daigaku Machi, Takatsuki Osaka Med Coll 2-7 Daigaku Machi Takatsuki Osaka Japan 5698686
Citazione:
M. Ohtani et al., "Impact of the expression of cyclin-dependent kinase inhibitor p27(Kip1) and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma", CANCER, 85(8), 1999, pp. 1711-1718

Abstract

BACKGROUND. The expression of p27(Kip1) and apoptosis have been implicatedin tumor aggressiveness and proved to be prognostic predictors for severalhuman malignancies. In this study, the authors sought to investigate the expression of p27(Kip1) and apoptosis and their potential significance in determining the prognosis of patients with non-early stage gastric carcinoma. METHODS. Primary gastric tumor specimens from 225 patients were investigated by immunohistochemistry with anti-p27(Kip1) and anti-Ki-67 antibodies, and their apoptotic indices were determined with the use of an Apop-Tag in situ detection kit. RESULTS, The median p27(Kip1) labeling index (LI) was 48.4%. There was a significant association between the p27 LIs and the apoptotic indices (AIs). However, there was no association between the p27 LIs and the Ki-67 LIs. p27 LI was demonstrated to be one of the most significant and independent prognostic factors in multivariate analysis. Although Al: was found to be prognostically significant in univariate analysis, it failed to retain an independent and significant value regarding overall survival in multivariate analysis. CONCLUSIONS. Decreased expression of p27(Kip1) and reduction of apoptotic potential were two of the most important factors in predicting a poor prognosis for patients with non-early stage gastric carcinoma. These findings support the hypothesis that decreased p27(Kip1) expression, which may reflecta decreased rate of apoptosis, is closely related to the aggressiveness ofgastric carcinoma. Therefore, the assessment of p27(Kip1) expression and apoptotic potential may prove valuable in identifying patients with gastric carcinoma who are at high risk for recurrence and would benefit from adjuvant therapy. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:29:17