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Titolo:
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
Autore:
Howlett, CJ; Bisson, SA; Resek, ME; Tigley, AW; Robbins, SM;
Indirizzi:
Univ Calgary, Dept Oncol, Canc Biol & Immunol Res Grp, Calgary, AB T2N 4N1, Univ Calgary Calgary AB Canada T2N 4N1 unol Res Grp, Calgary, AB T2N 4N1, Univ,Calgary, Dept Biochem & Mol Biol, Canc Biol & Immunol Res Grp, Calgary Univ Calgary Calgary AB Canada T2N 4N1 nc Biol & Immunol Res Grp, Calgary
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 257, anno: 1999,
pagine: 129 - 138
SICI:
0006-291X(19990402)257:1<129:TPPIAD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTEGRIN SIGNALING PATHWAY; PROTOONCOGENE PRODUCT CBL; RECEPTOR FUSION PROTEIN; SRC-FAMILY KINASES; FC-GAMMA-RI; C-CBL; PHOSPHATIDYLINOSITOL 3-KINASE; FUNCTIONAL ASSOCIATION; ESTROGEN-RECEPTOR; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Robbins, SM Univgary,ary, Dept Oncol, Canc Biol & Immunol Res Grp, 3330 Hosp Dr NW, Cal Univ Calgary 3330 Hosp Dr NW Calgary AB Canada T2N 4N1 NW, Cal
Citazione:
C.J. Howlett et al., "The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase", BIOC BIOP R, 257(1), 1999, pp. 129-138

Abstract

Hematopoietic cell kinase (Hck) is a member of the Src-family of protein tyrosine kinases. We have found that upon enzymatic activation of lick by the heavy metal mercuric chloride, there was a rapid increase in the levels of tyrosine phosphorylation of several proteins including the proto-oncogenep120(Cbl). Fibroblasts that are transformed with an activated allele of Hck exhibit constitutive Cbl phosphorylation. Upon Fc gamma receptor activation, a more physiologically relevant extracellular signal, Cbl is tyrosine phosphorylated and the Src-family selective inhibitor, PP1, can prevent thisphosphorylation on Cbl. Hck phosphorylates Cbl in vitro and the interaction between Cbl and Hck is direct, requiring Hck's unique, SH3 and SH2 domains for optimal binding. Using a novel estrogen-regulated chimera of Hck we have shown a hormone-dependent association between Hck and Cbl in murine fibroblasts. This work suggests that Cbl serves as a key mediator of Hck induced signalling in hematopoietic cells, (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:55:57