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Titolo:
Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1):Evidence for sterol-dependent regulation in macrophages
Autore:
Langmann, T; Klucken, J; Reil, M; Liebisch, G; Luciani, MF; Chimini, G; Kaminski, WE; Schmitz, G;
Indirizzi:
Univ Regensburg, Inst Clin Chem & Lab Med, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany CNRS Marseille Luminy, INSERM, Ctr Immunol, F-13288 Marseille 9, France CNRS Marseille Luminy Marseille France 9 ol, F-13288 Marseille 9, France
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 257, anno: 1999,
pagine: 29 - 33
SICI:
0006-291X(19990402)257:1<29:MCOTHA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-GLYCOPROTEIN; HUMAN CARBOXYLESTERASE; ABC TRANSPORTERS; PHOSPHATIDYLCHOLINE; TRANSLOCATION; FIBROBLASTS; EXPRESSION; MEMBRANES; PROMOTER; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ2Regensburg, Inst Clin Chem & Lab Med, Franz Josef Str Allee 11, D-9304 Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93042
Citazione:
T. Langmann et al., "Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1):Evidence for sterol-dependent regulation in macrophages", BIOC BIOP R, 257(1), 1999, pp. 29-33

Abstract

We have cloned the full-length cDNA for the human ATP binding cassette transporter 1 (hABC1). The 6603-bp open reading frame encodes a polypeptide of2201 amino acids resulting in a deduced molecular weight of 220 kDa. The hABC1 cDNA is highly homologous (62%) to the human rim ABC transporter (ABCR). hABC1 is expressed in a variety of human tissues with highest expressionlevels found in placenta, liver, lung, adrenal glands, and fetal tissues. We demonstrate that the hABC1 expression is induced during differentiation of human monocytes into macrophages in vitro. In macrophages, both the hABC1 mRNA and protein expression are upregulated in the presence of acetylatedlow-density lipoprotein (AcLDL). The AcLDL-induced increase in hABC1 expression is reversed by cholesterol depletion mediated by the addition of high-density lipoprotein (HDL,). Our data, demonstrating sterol-dependent regulation of hABC1 in human monocytes/macrophages, suggest a novel role for this transporter molecule in membrane lipid transport. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:43:33