Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors
Autore:
Fletcher, PJ; Korth, KM;
Indirizzi:
UnivON,ronto, Ctr Addict & Mental Hlth, Dept Psychol, Clarke Div, Toronto,Univ Toronto Toronto ON Canada Hlth, Dept Psychol, Clarke Div, Toronto,
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 183 - 193
SICI:
0955-8810(199903)10:2<183:RDDSAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTEX IN-VITRO; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; ACETYLCHOLINE-RELEASE; SEROTONIN AGONISTS; LOCOMOTOR-ACTIVITY; RAPHE NUCLEUS; RU 24969; RAT; COCAINE;
Keywords:
RU 24969; 5-HT1B; dopamine; amphetamine self-administration; conditioned reward; GR 127935; WAY 100635; nucleus accumbens; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, PJ Univ,Toronto, Ctr Addict & Mental Hlth, Dept Psychiat & Psychol, Clarke Div Univ Toronto 250 Coll St Toronto ON Canada ychol, Clarke Div
Citazione:
P.J. Fletcher e K.M. Korth, "RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors", BEHAV PHARM, 10(2), 1999, pp. 183-193

Abstract

Behavioural and neurochemical evidence indicates a facilitatory effect of 5-hydroxytryptamine (5-HT), acting via 5-HT1B receptors, on dopamine (DA) systems. To explore this interaction further, these experiments examined theeffects of the 5-HT1A/1B agonist RU-24969 on behaviours known to involve the mesolimbic DA system. These behaviours were locomotor activity, intravenous self-administration of d-amphetamine, responding for a conditioned reward (CR), and the response potentiating effects of amphetamine on CR responding. Locomotor activity was enhanced by 1 and 3 mg/kg RU 24969, and both doses also reduced responding for d-amphetamine (60 mu g/kg/infusion) Changing the unit dose produced a characteristic U-shaped dose response curve. This dose-response relationship was not apparent following injection of RU-24969. Across all unit infusion doses of amphetamine, the level of responding was fairly constant. In the CR experiments, rats responded for a conditioned stimulus that was previously paired with water. RU-24969 completely disrupted responding for CR, and also abolished CR responding in rats injected with 3 mu g d-amphetamine in the nucleus accumbens. RU-24969 also markedly suppressed responding for water. The suppressant actions of RU-24969 on amphetamine self-administration and CR responding involve stimulation of 5-HT1Breceptors, since they were reversed by the 5-HT1B/1D antagonist GR 127935 (3 mg/kg), but not by the 5-HT1A antagonist WAY-100635 (1 mg/kg). None of the behavioural effects of RU-24969 are consistent with a selective action to enhance mesolimbic DA function. Rather, global activation of 5-HT1B receptors appear to exert a general disruptive effect on operant responding. (C)1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:58:26