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Titolo:
Isolation rearing-induced disruption of prepulse inhibition: further evidence for fragility of the response
Autore:
Weiss, IC; Feldon, J; Domeney, AM;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 139 - 149
SICI:
0955-8810(199903)10:2<139:IRDOPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; SOCIAL-ISOLATION; ANTIPSYCHOTIC-DRUGS; LOCOMOTOR RESPONSE; ANIMAL-MODEL; REARED RATS; SCHIZOPHRENIA; AMPHETAMINE; DEFICITS; REFLEX;
Keywords:
social isolation; prepulse inhibition; locomotor activity; caging condition; Wistar rats; animal model; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Domeney, AM Swissh,ed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603Schwerzenbac Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
I.C. Weiss et al., "Isolation rearing-induced disruption of prepulse inhibition: further evidence for fragility of the response", BEHAV PHARM, 10(2), 1999, pp. 139-149

Abstract

The present study investigated isolation induced disruptions of prepulse inhibition (PPI), and effects on locomotor activity as a function of home caging condition (sawdust vs grid-floor) in the Wistar rat. Isolates reared in grid-floor cages did not show a disruption of PPI. However, when isolateswere reared in sawdust cages, a PPI deficit was evident. In an open field environment, isolates demonstrated significantly increased spontaneous locomotor activity compared to their group-housed counterparts, irrespective ofthe caging condition employed. Grouped animals reared in grid floor cages,however, showed reduced activity compared to grouped animals reared in sawdust cages. Although d-amphetamine treatment appeared to enhance locomotor activity selectively in isolates, particularly in those reared in grid-floor cages, this result could be explained by the existing pre-drug activity levels. With respect to PPI, not only were isolation-induced deficits in theWistar rat difficult to detect in a variable prepulse intensity PPI procedure, but when apparent, the deficits were of a fragile nature. The findingssuggest that caging condition may be a critical methodological factor in experiments investigating isolation-induced PPI deficits. Indeed, our results may indicate that rearing animals in grid-floor cages represents a form of chronic mild stress, which can interfere with normal sensorimotor gating mechanisms, in addition to other behaviours. (C) 1999 Lippincott Williams &Wilkins.

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Documento generato il 27/01/20 alle ore 16:46:43