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Titolo:
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze
Autore:
Schmitt, U; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 , Dept Psychiat, D-55101 Mainz, Germany
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 131 - 137
SICI:
0955-8810(199903)10:2<131:EOG(IO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; ANIMAL-MODELS; TEST BATTERY; ANXIETY; TIAGABINE; DIAZEPAM; BENZODIAZEPINES; ANTIDEPRESSANTS; PHARMACOLOGY; STRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55101 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55101 ermany
Citazione:
U. Schmitt e C. Hiemke, "Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze", BEHAV PHARM, 10(2), 1999, pp. 131-137

Abstract

The behavioural consequences of inhibition of gamma-aminobutyric acid (GABA) uptake were studied. Two GABA uptake inhibitors, tiagabine and SKF 89976-A, were administered to rats, and behaviour was analysed 30 min later in astandard open field, an enriched open field, and an elevated plus-maze. Eight groups of animals received either saline (0.9%), tiagabine, or SKF 89976-A. At a dose of 18.5 mg/kg, tiagabine, an established antiseizure drug, impaired motor coordination, enhanced exploratory activity and reduced anxiety related behaviour. SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might bea pharmacological strategy to treat not only epilepsy, but also anxiety disorders. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:20:41