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Titolo:
Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) andapo(a) fragments
Autore:
Mooser, V; Tinguely, F; Fontana, P; Lenain, V; Vaglio, M; Ruchat, P; von Segesser, LK; Marcovina, SM; Markert, M; Darioli, R; Nicod, P;
Indirizzi:
CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland CHU VaudoisLausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland CHU Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland CHU Vaudois, Cent Lab Clin Chem, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland CHU Vaudois, Med Policlin, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland Univ Washington, Dept Med, NW Lipid Res Labs, Seattle, WA USA Univ Washington Seattle WA USA t Med, NW Lipid Res Labs, Seattle, WA USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 1060 - 1065
SICI:
1079-5642(199904)19:4<1060:EOCBAH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY HEART-DISEASE; ACUTE-PHASE RESPONSE; LIPOPROTEIN(A) CONCENTRATIONS; HUMAN APOLIPOPROTEIN(A); RENAL-FAILURE; A-I; ELASTASE; URINE; CATABOLISM;
Keywords:
apolipoprotein(a); atherosclerosis; elastase; heparin; lipoprotein(a);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Mooser, V CHU Vaudois, Dept Internal Med, BH 19-135, CH-1011 Lausanne, Switzerland CHU Vaudois BH 19-135 Lausanne Switzerland CH-1011 Switzerland
Citazione:
V. Mooser et al., "Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) andapo(a) fragments", ART THROM V, 19(4), 1999, pp. 1060-1065

Abstract

Fragments of apolipoprotein(a) [apo(a)], the distinctive glycoprotein of lipoprotein(a) [Lp(a)], are present in human plasma and urine and have been implicated in the development of atherosclerosis. The mechanism responsiblefor the generation of apo(a) fragments in vivo is poorly understood, In this study, we examined the plasma levels of Lp(a) and apo(a) fragments [or free apo(a)] and urinary apo(a) in 15 subjects who underwent cardiac surgerynecessitating cardiopulmonary bypass. We also measured the plasma concentration and activity of polymorphonuclear elastase, an Lp(a)-cleaving enzyme in vitro, and plasma levels of C-reactive protein. Despite a marked activation of polymorphonuclear cells and a pronounced inflammatory response, as documented by an X-fold and a 35-fold increase in plasma levels of polymorphonuclear elastase and C-reactive protein, respectively, the proportion of plasma free apo(a) to Lp(a) and urinary excretion of apo(a) remained unchanged over a 7-day period after surgery, and polymorphonuclear elastase activity remained undetectable in plasma. No fragmentation of apo(a) was observedex vivo in plasma samples collected before and after surgery. These data indicate that in this model, apo(a) is not fragmented in plasma and are consistent with the hypothesis that apo(a) fragments result from a constitutively active tissue mechanism that is not modified by cardiac surgery with cardiopulmonary bypass.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 18:52:22