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Titolo:
Hormone replacement therapy, inflammation, and hemostasis in elderly women
Autore:
Cushman, M; Meilahn, EN; Psaty, BM; Kuller, LH; Dobs, AS; Tracy, RP;
Indirizzi:
Univ Vermont, Dept Med, Burlington, VT USA Univ Vermont Burlington VT USA niv Vermont, Dept Med, Burlington, VT USA Univ Vermont, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA London Sch Hyg & Trop Med, Dept Publ Hlth, London WC1, England London Sch Hyg & Trop Med London England WC1 l Hlth, London WC1, England Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Johns Hopkins Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ns Univ, Dept Med, Baltimore, MD USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 4, volume: 19, anno: 1999,
pagine: 893 - 899
SICI:
1079-5642(199904)19:4<893:HRTIAH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; CORONARY HEART-DISEASE; POSTMENOPAUSAL WOMEN; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SERUM-ALBUMIN; RISK; ESTROGEN; PLASMA; FIBRINOGEN;
Keywords:
blood coagulation; inflammation; hormone replacement therapy; elderly; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Cushman, M Univ Vermont, 55A S Pk Dr, Colchester, VT 05446 USA Univ Vermont 55A S Pk Dr Colchester VT USA 05446 , VT 05446 USA
Citazione:
M. Cushman et al., "Hormone replacement therapy, inflammation, and hemostasis in elderly women", ART THROM V, 19(4), 1999, pp. 893-899

Abstract

Lipid-lowering by postmenopausal hormone therapy (HRT) explains only partly the assumed coronary risk reduction associated with therapy. To explore other possible mechanisms, we studied associations of HRT use with inflammation and hemostasis risk markers in women greater than or equal to 65 years of age. Subjects were selected from 3393 participants in the fourth year examination of the Cardiovascular Health Study, an observational study of vascular disease risk factors. After excluding women with vascular disease, wecompared levels of inflammation and hemostasis variables in the 230 women using unopposed estrogen and 60 using estrogen/progestin, with those of 196nonusers selected as controls. Compared with nonusers, unopposed estrogen use was associated with 59% higher mean C-reactive protein (P<0.001), but with modestly lower levels of other inflammation indicators, fibrinogen, andalpha-1 acid glycoprotein (P<0.001). Factor VIIc was 16% higher among estrogen users (P<0.001), but this was not associated with higher thrombin production (prothrombin fragment 1-2), or increased fibrin breakdown (D-dimer). Concentration of plasminogen activator inhibitor-1 was 50% lower in both using groups (P<0.001) compared with nonusers, and this was associated with higher plasmin-antiplasmin complex: 8% higher in estrogen and 18% higher inestrogen/progestin users (P<0.05). Relationships between the markers and hormone use were less pronounced in estrogen/progestin users, with no association for C-reactive protein except in women in upper 2 tertiles of body mass index (P for interaction, 0.02). The direction and strength of the associations of HRT use with inflammation markers differed depending on the protein, so it is not clear whether HRT confers coronary risk reduction throughan inflammation-sensitive mechanism. Associations with hemostasis markers indicated no association with evidence of procoagulation and a possible association with increased fibrinolytic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:46:22