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Titolo:
Human immunodeficiency virus type 1 entry and chemokine receptors: a new therapeutic target
Autore:
Cammack, N;
Indirizzi:
Rocheandscovery Welwyn, Dept Virol, Welwyn Garden City AL7 3AY, Herts, Engl Roche Discovery Welwyn Welwyn Garden City Herts England AL7 3AY rts, Engl
Titolo Testata:
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 53 - 62
SICI:
0956-3202(199903)10:2<53:HIVT1E>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 DISEASE PROGRESSION; PROTEIN-COUPLED RECEPTOR; SMALL-MOLECULE INHIBITOR; LINE-TROPIC HIV-1; T-CELL; ENVELOPE GLYCOPROTEIN; CD4-INDEPENDENT INFECTION; CD4-MEDIATED FUSION; GENETIC RESTRICTION; CD4-POSITIVE CELLS;
Keywords:
HIV-1; virus entry; chemokine receptors; therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Cammack, N RocheAY,scovery Welwyn, Dept Virol, Broadwater Rd, Welwyn Garden City AL7 3 Roche Discovery Welwyn Broadwater Rd Welwyn Garden City Herts England AL7 3AY
Citazione:
N. Cammack, "Human immunodeficiency virus type 1 entry and chemokine receptors: a new therapeutic target", ANTIVIR CHE, 10(2), 1999, pp. 53-62

Abstract

After the identification of CD4 as the primary receptor for human immunodeficiency virus (HIV) type 1 entry into cells of the immune system, it soon became clear that CD4 alone was not sufficient to establish a productive infection. The search for the second receptors or co-receptors started over 10 years ago, and it was not until 1996 that the G protein-coupled 7-transmembrane receptors, CXCR4 and CCR5 were finally identified as the co-receptors for HIV-1 entry. The 7-transmembrane receptor family is a familiar therapeutic target for a number of diseases, and therefore these recent findings represent an exciting opportunity for new therapeutic approaches to the treatment of HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:10:36