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Titolo:
Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation
Autore:
Shin, LM; McNally, RJ; Kosslyn, SM; Thompson, WL; Rauch, SL; Alpert, NM; Metzger, LJ; Lasko, NB; Orr, SP; Pitman, RK;
Indirizzi:
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Psychiat, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Radiol, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 t Neurol, Boston, MA 02114 USA Tufts Univ, Dept Psychol, Medford, MA 02155 USA Tufts Univ Medford MA USA02155 Univ, Dept Psychol, Medford, MA 02155 USA Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 Dept Psychol, Cambridge, MA 02138 USA VA Res Serv, Manchester, NH USA VA Res Serv Manchester NH USAVA Res Serv, Manchester, NH USA Harvard Med Sch, Boston, MA USA Harvard Med Sch Boston MA USAHarvard Med Sch, Boston, MA USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 4, volume: 156, anno: 1999,
pagine: 575 - 584
SICI:
0002-953X(199904)156:4<575:RCBFDS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; POSITRON EMISSION TOMOGRAPHY; FUNCTIONAL NEUROANATOMY; SYMPTOM PROVOCATION; FACIAL EXPRESSIONS; VISUAL-IMAGERY; HUMAN AMYGDALA; HAPPINESS; ANXIETY; SADNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, LM MassachusettshGen Hosp, Psychiat Neurosci Program, E Bldg 149,Room 9147,13t Massachusetts Gen Hosp E Bldg 149,Room 9147,13th St Charlestown MA USA 02129
Citazione:
L.M. Shin et al., "Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation", AM J PSYCHI, 156(4), 1999, pp. 575-584

Abstract

Objective: The purpose of this study was to determine whether anterior limbic and paralimbic regions of the brain are differentially activated duringthe recollection and imagery of traumatic events in trauma-exposed individuals with and without posttraumatic stress disorder (PTSD). Method: Positron emission tomography (PET) was used to measure normalized regional cerebral blood flow (CBF) in 16 women with histories of childhood sexual abuse: eight with current PTSD and eight without current PTSD. In separate script-driven imagery conditions, participants recalled and imagined traumatic and neutral autobiographical events. Psychophysiologic responses and subjective ratings of emotional state were measured for each condition. Results: In the traumatic condition versus the neutral control conditions, both groups exhibited regional CBF increases in orbitofrontal cortex and anterior temporal poles; however, these increases were greater in the PTSD group than in the comparison group. The comparison group exhibited regional CBF increases in insular cortex and anterior cingulate gyrus; increases in anterior cingulate gyrus were greater in the comparison group than in the PTSD group. Regional CBF decreases in bilateral anterior frontal regions were greater in the PTSD group than in the comparison group, and only the PTSD group exhibited regional CBF decreases in left inferior frontal gyrus. Conclusions: The recollection and imagery of traumatic events versus neutral events was accompanied by regional CBF increases in anterior paralimbic regions of the brain in trauma-exposed individuals with and without PTSD. However, the PTSD group had greater increases in orbitofrontal cortex and anterior temporal pole, whereas the comparison group had greater increases in anterior cingulategyrus.

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Documento generato il 14/07/20 alle ore 06:29:19