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Titolo:
Effects of granulocyte colony-stimulating factor on night sleep in humans
Autore:
Schuld, A; Mullington, J; Hermann, D; Hinze-Selch, D; Fenzel, T; Holsboer, F; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 45, anno: 1999,
pagine: R1149 - R1155
SICI:
0363-6119(199904)45:4<R1149:EOGCFO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CYTOKINE RECEPTOR LEVELS; FACTOR-ALPHA; PLASMA CYTOKINE; HEALTHY-MEN; INTERLEUKIN-1; THALIDOMIDE; ENDOTOXIN; CLOZAPINE; BRAIN;
Keywords:
tumor necrosis factor-alpha; interleukin-1 beta; soluble tumor necrosis factor receptors; interleukin-1 receptor antagonist; non-rapid eye movement sleep;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "Effects of granulocyte colony-stimulating factor on night sleep in humans", AM J P-REG, 45(4), 1999, pp. R1149-R1155

Abstract

Numerous animal studies suggest that cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) mediate increased sleep amount and intensity observed during infection and are, moreover, involved in physiological sleep regulation. In humans the role of cytokines in sleep-wake regulation is largely unknown. In a single-blind, placebo-controlled study, we investigated the effects of granulocyte colony-stimulating factor (G-CSF, 300 mu g sc) on the plasma levels of cytokines, soluble cytokine receptors, and hormones as well as on night sleep. CT-CSF did not affect rectal temperature or the plasma levels of cortisol and growth hormone but did induce increases in the plasma levels of IL-1 receptor antagonist andboth soluble TNF receptors within 2 h after injection. In parallel, the amount of slow-wave sleep and electroencephalographic delta power were reduced, indicating a lowered sleep intensity. We conclude that G-CSF suppresses sleep intensity via increased circulating amounts of endogenous antagonistsof IL-1 beta and TNF-alpha activity, suggesting that these cytokines are involved in human sleep regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:43:08