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Titolo:
Glutamatergic and dopaminergic contributions to rat bladder hyperactivity after cerebral artery occlusion
Autore:
Yokoyama, O; Yoshiyama, M; Namiki, M; De Groat, WC;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Urol, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 45, anno: 1999,
pagine: R935 - R942
SICI:
0363-6119(199904)45:4<R935:GADCTR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; MICTURITION REFLEX; URINARY-BLADDER; MONOAMINERGIC SYSTEMS; ANESTHETIZED RATS; MK-801; NEURONS; MOTILITY; ACTIVATION; MODULATION;
Keywords:
brain ischemia; micturition reflex; glutamate; MK-801; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, O Kanazawa08641, Sch Med, Dept Urol, 13-1 Takara Machi, Kanazawa, Ishikawa 92 Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208641
Citazione:
O. Yokoyama et al., "Glutamatergic and dopaminergic contributions to rat bladder hyperactivity after cerebral artery occlusion", AM J P-REG, 45(4), 1999, pp. R935-R942

Abstract

The contribution of glutamatergic and dopaminergic mechanisms to bladder hyperactivity after left middle cerebral artery occlusion was evaluated by determining the effects of intravenous cumulative doses of an N-methyl-D-aspartate (NMDA) glutamatergic antagonist (MK-801) and D-1-selective (Sch-23390), Da-selective (sulpiride), or nonselective (haloperidol) dopaminergic antagonists on bladder activity in sham-operated (SO) and cerebral-infarcted (CI) rats. MK-801 (1 and 10 mg/kg) or sulpiride (3-30 mg/kg) significantly increased bladder capacity (BC) in CI but decreased or had no effect, respectively, on BC in SO. Sch-23390 (0.1-3 mg/kg) decreased BC in both SO and CI. In both CI and SO, low doses of haloperidol (0.1-1 mg/kg) increased BC, but a higher dose (3 mg/kg) reversed this effect. Administration of haloperidol (0.3 mg/kg) or sulpiride (10 mg/kg) in combination with MK-801 (0.01-10 mg/kg) markedly increased BC in CI but produced small decreases or increases in BC depending on the dose of MK-801 in SO. These results indicate that the bladder hyperactivity induced by cerebral infarction is mediated in part by NMDA glutamatergic and D-2 dopaminergic excitatory mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:22:40