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Titolo:
Hypoxic contraction of small pulmonary arteries from normal and endotoxemic rats: fundamental role of NO
Autore:
Terraz, S; Baechtold, F; Renard, D; Barsi, A; Rosselet, A; Gnaegi, A; Liaudet, L; Lazor, R; Haefliger, JA; Schaad, N; Perret, C; Kucera, P; Markert, M; Feihl, F;
Indirizzi:
Univ Lausanne Hosp, Div Clin Pathophysiol & Med Teaching, CH-1011 Lausanne, Univ Lausanne Hosp Lausanne Switzerland CH-1011 ching, CH-1011 Lausanne, Univzerlandne Hosp, Mol Biol Lab, Dept Internal Med, CH-1011 Lausanne, Swit Univ Lausanne Hosp Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Swit Univ Lausanne Hosp, Cent Lab Clin Chem, CH-1011 Lausanne, Switzerland UnivLausanne Hosp Lausanne Switzerland CH-1011 11 Lausanne, Switzerland Univ Lausanne, Sch Med, Inst Physiol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 CH-1005 Lausanne, Switzerland Pharm Interhosp La Cote, CH-1110 Morges, Switzerland Pharm Interhosp La Cote Morges Switzerland CH-1110 0 Morges, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 45, anno: 1999,
pagine: H1207 - H1214
SICI:
0363-6135(199904)45:4<H1207:HCOSPA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; L-ARGININE; VASCULAR REACTIVITY; VASOCONSTRICTION; ENDOTHELIUM; INHIBITION; RESPONSES; AORTA; MECHANISMS; ISOFORMS;
Keywords:
pulmonary circulation; hypoxia; vascular endothelium; nitric oxide; endotoxin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Feihl, F Univ Lausanne Hosp, Div Clin Pathophysiol & Med Teaching, BH19-313, CH-1011 Univ Lausanne Hosp BH19-313 Lausanne Switzerland CH-1011 CH-1011
Citazione:
S. Terraz et al., "Hypoxic contraction of small pulmonary arteries from normal and endotoxemic rats: fundamental role of NO", AM J P-HEAR, 45(4), 1999, pp. H1207-H1214

Abstract

The present study was aimed at examining the role of nitric oxide (NO) in the hypoxic contraction of isolated small pulmonary arteries (SPA) in the rat. Animals were treated with either saline (sham experiments) or Escherichia coli lipolysaccharide [LPS, to obtain expression of the inducible NO synthase (iNOS) in the lung] and killed 4 h later. SPA(300- to 600-mu m outer diameter) were mounted as rings in organ chambers for the recording of isometric tension, precontracted with PGF(2 alpha), and exposed to either severe (bath PO2 8 +/- 3 mmHg) or milder (21 +/- 3 mmHg) hypoxia. In SPA from sham-treated rats, contractions elicited by severe hypoxia were completely suppressed by either endothelium removal or preincubation with an NOS inhibitor [N-G-nitro-L-arginine methyl ester (L-NAME), 10(-3) M]. In SPA from LPS-treated rats, contractions elicited by severe hypoxia occurred irrespectiveof the presence or absence of endothelium and were largely suppressed by L-NAME. The milder hypoxia elicited no increase in vascular tone. These results indicate an essential role of NO in the hypoxic contractions of precontracted rat SPA. The endothelium independence of HPV in arteries from LPS-treated animals appears related to the extraendothelial expression of iNOS. The severe degree of hypoxia required to elicit any contraction is consistent with a mechanism of reduced NO production caused by a limited availability of O-2 as a substrate for NOS.

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Documento generato il 05/07/20 alle ore 01:09:50