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Titolo:
Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart
Autore:
Kobayashi, T; Miyauchi, T; Sakai, S; Kobayashi, M; Yamaguchi, I; Goto, K; Sugishita, Y;
Indirizzi:
Univarakiuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Tsukuba, Ib Univ Tsukuba Tsukuba Ibaraki Japan 3058575 d, Div Cardiovasc, Tsukuba, Ib Univ Tsukuba, Inst Basic Med Sci, Dept Pharmacol, Tsukuba, Ibaraki 3058575, Univ Tsukuba Tsukuba Ibaraki Japan 3058575 col, Tsukuba, Ibaraki 3058575, Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, JapanBanyu Pharmaceut Co Ltd Tsukuba Ibaraki Japan 3002611 raki 3002611, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 45, anno: 1999,
pagine: H1197 - H1206
SICI:
0363-6135(199904)45:4<H1197:EOEEAE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; MESSENGER-RNA; ENDOGENOUS ENDOTHELIN-1; FUNCTIONAL EXPRESSION; CONVERTING ENZYME; PLASMA ENDOTHELIN; CARDIAC MYOCYTES; GENE-EXPRESSION; FAILURE; CLONING;
Keywords:
heart failure; endothelin-receptor subtypes; endothelin-converting enzyme; angiotensin-converting enzyme;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Miyauchi, T Univarakiuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Tsukuba, Ib Univ Tsukuba Tsukuba Ibaraki Japan 3058575 ovasc, Tsukuba, Ib
Citazione:
T. Kobayashi et al., "Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart", AM J P-HEAR, 45(4), 1999, pp. H1197-H1206

Abstract

Endothelin (ET)-1 has a positive inotropic effect and induces hypertrophy in cardiomyocytes. We previously reported that the peptide level of ET-1 isincreased in the failing heart of rats with chronic heart failure (CHF) and that treatment with an ETA-receptor antagonist greatly improves survival in rats with CHF. However, precise analysis for alteration of the myocardial ET system in the failing heart is not known. In this study, we used rats with CHF due to chronic myocardial infarction. Sham-operated rats served asa control. The results showed that the level of preproendothelin (preproET)-1 mRNA and the peptide level of ET-1 were markedly increased in the heartof rats with CHF, whereas the expression of endothelin-converting enzyme (ECE)-1 mRNA in the heart did not differ between CHF and control rats. The intensity of ET-1 staining (ET-1-like immunoreactivity) in cardiomyocytes was markedly stronger in rats with CHF than in control rats, and the fibrotictissues of the infarcted area were not stained. The mRNA and protein levels of both ETA and ETB receptors in the heart were significantly higher in rats with CHF than in control rats. The present study suggests that the increase in ET-1 peptide level in the heart of the rats with CHF originated from upregulation of preproET-1 mRNA, which was not attendant with the alteration of ECE-I mRNA expression, and that both the ETA- and ETB-receptor systems are greatly accelerated in the failing heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:21:52