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Titolo:
Cutaneous Waldenstrom macroglobulinemia in transformation
Autore:
Appenzeller, P; Leith, CP; Foucar, K; Scott, AA; Bigler, CF; Thompson, CT;
Indirizzi:
Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA UnivNew Mexico Albuquerque NM USA 87131 athol, Albuquerque, NM 87131 USA Univ New Mexico, Hlth Sci Ctr, Dept Dermatol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 matol, Albuquerque, NM 87131 USA
Titolo Testata:
AMERICAN JOURNAL OF DERMATOPATHOLOGY
fascicolo: 2, volume: 21, anno: 1999,
pagine: 151 - 155
SICI:
0193-1091(199904)21:2<151:CWMIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOBLASTIC LYMPHOMA; CELL LYMPHOMA; MANIFESTATIONS; PATIENT; DISEASE; KI-67; SKIN;
Keywords:
Waldenstrom macroglobulinemia; immunohistochemistry; Ki-67; lymphoproliferative disorder; lymphoplasmacytic; immunoblastic lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, CT Unive,ew Mexico Hosp, Dept Pathol, 2nd Floor,2211 Lomas Blvd NE, Albuquerqu Univ New Mexico Hosp 2nd Floor,2211 Lomas Blvd NE Albuquerque NM USA 87106
Citazione:
P. Appenzeller et al., "Cutaneous Waldenstrom macroglobulinemia in transformation", AM J DERMAT, 21(2), 1999, pp. 151-155

Abstract

Waldenstrom macroglobulinemia is a low-grade B-cell lymphoproliferative disorder of the elderly with characteristic monoclonal IgM-producing neoplastic infiltrates of the bone marrow, lymph node, and spleen. Cutaneous manifestations are usually nonspecific such as purpura, ulcers, and urticarial lesions. These lesions are caused by hyperviscosity of the blood, immune complex-mediated vascular damage, paraprotein deposition, and amyloid deposition. Specific skin lesions occur rarely and generally consist of translucent,flesh-colored papules composed of monoclonal IgM deposits. Rarely, there may be violaceous lesions composed of low-grade lymphoplasmacytic infiltrates characteristic of Waldenstrom macroglobulinemia. Both cutaneous manifestations of the disease, as well as disease transformation to high-grade, large cell lymphoma are rare. We report two very unusual cases of Waldenstrom macroglobulinemia with documented skin disease that demonstrated transformation to high-grade lymphoma. Both patients were elderly men with long-standing Waldenstrom macroglobulinemia involving the bone marrow, who subsequently developed skin involvement by the disease. Waldenstrom macroglobulinemia can rarely manifest as cutaneous disease, sometimes as a high-grade transformation of low-grade Waldenstrom macroglobulinemia elsewhere. Distinction of cases of transformed Waldenstrom macroglobulinemia from de novo cutaneouslarge cell lymphoma may be important, because the two entities are likely biologically different.

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Documento generato il 10/07/20 alle ore 02:22:35