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Titolo:
Variability of myocardium at risk for acute myocardial infarction
Autore:
Klarich, KW; Christian, TF; Higano, ST; Gibbons, RJ;
Indirizzi:
Mayo5Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 5590 Mayo Clin & Mayo Fdn Rochester MN USA 55905 ernal Med, Rochester, MN 5590
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 8, volume: 83, anno: 1999,
pagine: 1191 - 1195
SICI:
0002-9149(19990415)83:8<1191:VOMARF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEXAKIS 2-METHOXYISOBUTYL ISONITRILE; EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; TC-99M SESTAMIBI; METHOXYISOBUTYL ISONITRILE; CONSCIOUS DOG; SIZE; AREA; QUANTIFICATION; REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Klarich, KW Mayohester, Mayo Fdn, Div Cardiovasc Dis & Internal Med, 200 1st St SW, Roc Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 Roc
Citazione:
K.W. Klarich et al., "Variability of myocardium at risk for acute myocardial infarction", AM J CARD, 83(8), 1999, pp. 1191-1195

Abstract

The objective of this study was to assess the variability in myocardium atrisk and relate this to coronary angiographic variables. One hundred ninety-seven patients with greater than or equal to 1-mm ST-segment elevation in2 contiguous electrocardiographic leads, without prior myocardial infarction, were injected with technetium-99m sestamibi acutely before reperfusion therapy. The perfusion defect was quantified to determine myocardium at risk for infarction. patients underwent coronary angiography to determine the infarct-related artery and to classify the occlusion as proximal or not proximal. Collateral and anterograde (Thrombolysis In Myocardial Infarction [TIMI] trial) flow were assessed in a subset of 83 patients with angiography before direct angioplasty. Myocardium at risk for infarction in the distribution of the left anterior descending coronary artery was significantly greater (p <0.0001) than that in the circumflex or right coronary artery. In the left anterior descending coronary artery distribution, myocardium at risk for infarction was significantly larger for proximal occlusions (p <0.0001). There was a trend toward greater myocardium at risk for infarction of proximal occlusions (p = 0.14) of the left circumflex but not for proximal occlusions in the right coronary artery distribution (p = 0.47). Multivariate analysis revealed that the infarct-related artery (p <0.0001), TIMI flow (p = 0.0002), and proximal location (p = 0.09) in the infarct-related artery were independent predictors of myocardium at risk for infarction. Thus, infarct related artery, TIMI flow, and proximal location of occlusion in theinfarct-related artery influence the myocardium at risk for infarction, which is highly variable for given location of occlusion. (C)1999 by ExcerptaMedica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:07:41