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Titolo:
CHANGES IN PLASMA T-3 DURING FASTING REFEEDING IN TILAPIA (OREOCHROMIS-NILOTICUS) ARE MAINLY REGULATED THROUGH CHANGES IN HEPATIC TYPE-II IODOTHYRONINE DEIODINASE/
Autore:
VANDERGEYTEN S; MOL KA; PLUYMERS W; KUHN ER; DARRAS VM;
Indirizzi:
CATHOLIC UNIV LOUVAIN,COMPARAT ENDOCRINOL LAB,NAAMSESTR 61 B-3000 LOUVAIN BELGIUM CATHOLIC UNIV LOUVAIN,COMPARAT ENDOCRINOL LAB B-3000 LOUVAIN BELGIUM
Titolo Testata:
Fish physiology and biochemistry
fascicolo: 2, volume: 19, anno: 1998,
pagine: 135 - 143
SICI:
0920-1742(1998)19:2<135:CIPTDF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT ONCORHYNCHUS-MYKISS; THYROXINE 5'-MONODEIODINASE ACTIVITY; RED-BLOOD-CELLS; RAINBOW-TROUT; GROWTH-HORMONE; SALMO-GAIRDNERI; FOOD RESTRICTION; LIVER; 3,5,3'-TRIIODO-L-THYRONINE; RAT;
Keywords:
THYROID HORMONE; T-3; T-4; IODOTHYRONINE DEIODINASES; FASTING; REFEEDING; FISH; TILAPIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Vandergeyten et al., "CHANGES IN PLASMA T-3 DURING FASTING REFEEDING IN TILAPIA (OREOCHROMIS-NILOTICUS) ARE MAINLY REGULATED THROUGH CHANGES IN HEPATIC TYPE-II IODOTHYRONINE DEIODINASE/", Fish physiology and biochemistry, 19(2), 1998, pp. 135-143

Abstract

Fasting and refeeding have considerable effects on thyroid hormone metabolism. In tilapia (Oreochromis niloticus), fasting results in lowerplasma T-3 and T-4 concentrations when compared to the nd libitum fedanimals. This is accompanied by a decrease in hepatic type II (D2) and in brain and gill type III (D3) activity. No changes in kidney type I (D1) activity are observed. Refeeding results in a rapid restorationof plasma T-4 values but not of plasma T-3 Plasma T-3 remains low fortwo days of refeeding before increasing to normal levels. Liver D2 and gill D3 also do not increase until two days after refeeding. Brain D3, on the other hand, rises immediately upon refeeding. These results suggest that the change in hepatic D2 activity is one of the main factors responsible for the changes in plasma T-3 observed during starvation and refeeding in tilapia. This finding supports the hypothesis that, in contrast to mammals and birds, liver D2 is the primary source of plasma T-3 in fish. Although the deiodinases important for the gross regulation of plasma T-3 during fasting/refeeding differ (mammals: D1 and D3, birds: D3, fish: D2), they all occur in the liver, suggesting that the organ itself may play a crucial role. In addition, the changesin brain and gill D3 suggest that these enzymes constitute a fine tuning mechanism for regulation of T-3 availability at the cellular or plasma levels, respectively.

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Documento generato il 10/07/20 alle ore 09:41:45