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Titolo:
THE EFFECT OF DIFFERENT ANTITHROMBOTIC REGIMENS ON PLATELET-AGGREGATION AFTER MYOCARDIAL-INFARCTION
Autore:
HURLEN M; SELJEFLOT I; ARNESEN H;
Indirizzi:
ULLEVAL UNIV HOSP,RES FORUM,DEPT CARDIOL N-0407 OSLO NORWAY ULLEVAL UNIV HOSP,DEPT CARDIOL OSLO NORWAY
Titolo Testata:
SCANDINAVIAN CARDIOVASCULAR JOURNAL
fascicolo: 4, volume: 32, anno: 1998,
pagine: 233 - 237
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE ASPIRIN THERAPY; BETA-THROMBOGLOBULIN; RELEASE; DISEASE; STROKE; ANGINA; TRIAL; SIZE;
Keywords:
ACETYLSALICYLIC ACID NONRESPONSIVENESS; MYOCARDIAL INFARCTION; PLATELET AGGREGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Hurlen et al., "THE EFFECT OF DIFFERENT ANTITHROMBOTIC REGIMENS ON PLATELET-AGGREGATION AFTER MYOCARDIAL-INFARCTION", SC CARDIOVA, 32(4), 1998, pp. 233-237

Abstract

Platelet aggregate ratio (PAR) was measured according to the method of Wu & Hoak in 143 patients after acute myocardial infarction (AMI) and in 54 controls. A PAR < 1 expresses the presence of platelet aggregates. The patients were randomized to aspirin 160 mg/, or warfarin, or aspirin 75 mg/d + warfarin. In patients on aspirin, PAR was measured 24 h after aspirin intake, and in 76 patients also 2 h after aspirin. The median PAR in patients on warfarin was 0.85, on warfarin + aspirin 0.91 and on aspirin alone 0.94, all significantly lower than the median PAR of 0.97 in the controls. In 14 patients on aspirin the PARs werebelow a cut-off point of 0.82 (secondary aspirin non-responders). PARincreased significantly 2 h after aspirin intake. In two patients, however, PAR remained low (primary aspirin non-responders). It is concluded that some patients do not seem to respond to aspirin, the clinicalimplication of which has yet to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:10:36