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Titolo:
FEVER OR A SOAR THROAT AFTER START OF ANTITHYROIDAL DRUGS - A MEDICALEMERGENCY
Autore:
ROELOFFZEN WWH; VERHAEGH JJ; VANPOELGEEST AE; GANSEVOORT RT;
Indirizzi:
UNIV GRONINGEN HOSP,DEPT INTERNAL MED,POB 3001 NL-9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT INTERNAL MED NL-9700 RB GRONINGEN NETHERLANDS TWENTEBORG HOSP,DEPT INTERNAL MED ALMELO NETHERLANDS
Titolo Testata:
Netherlands journal of medicine
fascicolo: 3, volume: 53, anno: 1998,
pagine: 113 - 117
SICI:
0300-2977(1998)53:3<113:FOASTA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; METHIMAZOLE-INDUCED AGRANULOCYTOSIS; FACTOR G-CSF; GRAVES-DISEASE; PROPYLTHIOURACIL; PATIENT;
Keywords:
AGRANULOCYTOSIS; LEUKOPENIA; ANTITHYROID DRUGS (METHIMAZOLE, CARBIMAZOLE, PTU); PREVENTION; GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
W.W.H. Roeloffzen et al., "FEVER OR A SOAR THROAT AFTER START OF ANTITHYROIDAL DRUGS - A MEDICALEMERGENCY", Netherlands journal of medicine, 53(3), 1998, pp. 113-117

Abstract

We describe two patients who developed granulocytopenia (granulocyte count < 1.0 x 10(9)/l) after treatment with antithyroid drugs. Although, perhaps, an already known side-effect of these drugs, we present these cases in order to stay alert for this serious complication. The first patient developed granulocytopenia upon reinstitution of propylthiouracil after an uncomplicated first course of ATD-treatment. In the second case we report the use of granulocyte colony-stimulating factor (G-CSF) for treatment of a patient with methimazole-induced granulocytopenia. Furthermore, we discuss current concepts concerning pathophysiology, prevention and therapy. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:28:50