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Titolo:
2 DISTINCT NICOTINIC RECEPTORS, ONE PHARMACOLOGICALLY SIMILAR TO THE VERTEBRATE ALPHA-7-CONTAINING RECEPTOR, MEDIATE CL CURRENTS IN APLYSIANEURONS
Autore:
KEHOE J; MCINTOSH JM;
Indirizzi:
ECOLE NORMALE SUPER,NEUROBIOL LAB,46 RUE ULM F-75005 PARIS FRANCE UNIV UTAH,DEPT PSYCHIAT SALT LAKE CITY UT 84112 UNIV UTAH,DEPT BIOL SALT LAKE CITY UT 84112
Titolo Testata:
The Journal of neuroscience
fascicolo: 20, volume: 18, anno: 1998,
pagine: 8198 - 8213
SICI:
0270-6474(1998)18:20<8198:2DNROP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER HAIR-CELLS; BUNGAROTOXIN BINDING-SITES; MAMMALIAN BC3H-1 CELLS; ALPHA-CONOTOXIN-IMI; GATED ION CHANNELS; ACETYLCHOLINE-RECEPTORS; XENOPUS-OOCYTES; GABA(C) RECEPTORS; COMPETITIVE ANTAGONISTS; CHOLINERGIC INHIBITION;
Keywords:
NICOTINIC RECEPTOR; ACETYLCHOLINE; ALPHA-7; CHLORIDE; APLYSIA; ALPHA-CONOTOXIN IMI; SUBERYLDICHOLINE; METHYLLYCACONITINE; ALPHA-BUNGAROTOXIN; STRYCHNINE; DIHYDRO-BETA-ERYTHROIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
J. Kehoe e J.M. Mcintosh, "2 DISTINCT NICOTINIC RECEPTORS, ONE PHARMACOLOGICALLY SIMILAR TO THE VERTEBRATE ALPHA-7-CONTAINING RECEPTOR, MEDIATE CL CURRENTS IN APLYSIANEURONS", The Journal of neuroscience, 18(20), 1998, pp. 8198-8213

Abstract

Ionotropic, nicotinic receptors have previously been shown to mediateboth inhibitory (Cl-dependent) and excitatory (cationic) cholinergic responses in Aplysia neurons. We have used fast perfusion methods of agonist and antagonist application to reevaluate the effects on these receptors of a wide variety of cholinergic compounds, including a number of recently isolated and/or synthesized alpha toxins [alpha-conotoxin (alpha CTx)] from Conus snails. These toxins have been shown in previous studies to discriminate between the many types of nicotinic receptors now known to be expressed in vertebrate muscle, neuroendocrine, and neuronal cells. One of these toxins (alpha CTx ImI from the worm-eating snail Conus imperialis) revealed that two kinetically and pharmacologically distinct elements underlie the ACh-induced Cl-dependent response in Aplysia neurons: one element is a rapidly desensitizing current that is blocked by the toxin; the other is a slowly desensitizing current that is unaffected by the toxin. The two kinetically defined elements were also found to be differentially sensitive to different agonists. Finally, the proportion of the rapidly desensitizing element tothe sustained element was found to be cell-specific. These observations led to the conclusion that two distinct nicotinic receptors mediateCl currents in Aplysia neurons. The receptor mediating the rapidly desensitizing Cl-dependent response shows a strong pharmacological resemblance to the vertebrate alpha-bungarotoxin-sensitive, alpha 7-containing receptor, which is permeable to calcium and mediates a rapidly desensitizing excitatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:22:29