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Titolo:
SIMULTANEOUS GLUTAMATE AND PERFUSION FMRI RESPONSES TO REGIONAL BRAIN-STIMULATION
Autore:
FORMAN SD; SILVA AC; DEDOUSIS N; BARBIER EL; FERNSTROM JD; KORETSKY AP;
Indirizzi:
UPMC,BST W 1642,3811 OHARA ST PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 15260 PITTSBURGH VET AFFAIRS HEALTHCARE SYST PITTSBURGH PA 00000 CARNEGIE MELLON UNIV,DEPT BIOL SCI PITTSBURGH PA 15213 CARNEGIE MELLON UNIV,PITTSBURGH NMR CTR BIOMED RES PITTSBURGH PA 15213 CARNEGIE MELLON UNIV,CTR NEURAL BASIS COGNIT PITTSBURGH PA 15213
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 10, volume: 18, anno: 1998,
pagine: 1064 - 1070
SICI:
0271-678X(1998)18:10<1064:SGAPFR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; ARTERIAL WATER; NITRIC-OXIDE; SENSORY STIMULATION; RAT; MICRODIALYSIS; INVERSION; TIME;
Keywords:
MICRODIALYSIS; PICROTOXIN; REGIONAL CEREBRAL BLOOD FLOW; BRAIN MAPPING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Forman et al., "SIMULTANEOUS GLUTAMATE AND PERFUSION FMRI RESPONSES TO REGIONAL BRAIN-STIMULATION", Journal of cerebral blood flow and metabolism, 18(10), 1998, pp. 1064-1070

Abstract

Functional magnetic resonance imaging (fMRI) rests on the assumption that regional brain activity is closely coupled to regional cerebral blood flow (rCBF) in vivo. To test the degree of coupling, cortical brain activity was locally stimulated in rats by reversed microdialysis infusion of picrotoxinin, a gamma-aminobutyric acid-A antagonist. Before and during the first 30 minutes of infusion, simultaneous fMRI (rCBF) and neurochemical (interstitial glutamate concentration) measures ofbrain activity were highly correlated (r = 0.83). After 30 minutes ofpicrotoxinin-induced stimulation, glutamate levels decreased but rCBFremained elevated, suggesting that additional factors modulate the relationship between neuronal neurotransmitters and hemodynamics at these later stages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:28:13