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Titolo:
POLYCLONAL MONOCLONAL RATIO IN KIDNEY AND BONE-MARROW TRANSPLANTED PATIENTS TREATED WITH CYCLOSPORINE/
Autore:
CAPONE D; DEMARINO V; CASO N; STANZIALE P; FONTANA R; IMPERATORE P; DEMARINO V; PISANTI N;
Indirizzi:
FARMACOL POLICLIN,VIA S PANSINI 5 I-80131 NAPLES VOMERO ITALY UNIV NAPLES FEDERICO II,DEPT NEUROSCI,PHARMACOL SECT NAPLES ITALY
Titolo Testata:
Clinical transplantation
fascicolo: 5, volume: 12, anno: 1998,
pagine: 430 - 433
SICI:
0902-0063(1998)12:5<430:PMRIKA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUORESCENCE POLARIZATION IMMUNOASSAY; MONOCLONAL RADIOIMMUNOASSAY; RENAL-TRANSPLANTATION; ASSAY-METHODS; BLOOD; PHARMACOKINETICS; NEPHROTOXICITY; REJECTION;
Keywords:
CYCLOSPORINE; POLYCLONAL/MONOCLONAL RATIO; RENAL AND BONE MARROW TRANSPLANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Capone et al., "POLYCLONAL MONOCLONAL RATIO IN KIDNEY AND BONE-MARROW TRANSPLANTED PATIENTS TREATED WITH CYCLOSPORINE/", Clinical transplantation, 12(5), 1998, pp. 430-433

Abstract

On 296 blood samples obtained from 22 bone marrow and 21 kidney transplanted patients, the concomitant measurements of polyclonal and monoclonal cyclosporine (CsA) were performed and the relative polyclonal/monoclonal (P/M) ratios were calculated. Biochemical profiles of kidney and liver functions were also determined in all patients. For each type of transplant, biochemical data were divided into two subgroups on the basis of P/M ratio: A) data obtained in patients with P/M ratio > 3.0; B) data obtained in patients with P/M ratio less than or equal to 3.0. While in kidney transplanted patients no difference of biochemical profiles was found between two subgroups, in bone marrow transplant recipients the subgroup A showed a worsening of hepatic function parameters as compared to subgroup B. Therefore, it appears that P/M ratio could represent in bone marrow transplantation an index of hepatic CsAtoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:19:59