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Titolo:
ASSOCIATION OF FUNGAL COLONIZATION AND INVASIVE DISEASE IN VERY-LOW-BIRTH-WEIGHT INFANTS
Autore:
HUANG YC; LI CC; LIN TY; LIEN RI; CHOU YH; WU JL; HSUEH C;
Indirizzi:
CHANG GUNG CHILDRENS HOSP,DIV INFECT DIS,5 FU SHIN ST TAYUAN TAIWAN CHANG GUNG CHILDRENS HOSP,DIV NEONATOL TAYUAN TAIWAN CHANG GUNG MEM HOSP,DEPT CLIN PATHOL TAYUAN TAIWAN
Titolo Testata:
The Pediatric infectious disease journal
fascicolo: 9, volume: 17, anno: 1998,
pagine: 819 - 822
SICI:
0891-3668(1998)17:9<819:AOFCAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSIVE-CARE UNIT; CANDIDA; OUTBREAK; NURSERY;
Keywords:
FUNGAL COLONIZATION; INVASIVE CANDIDIASIS; VERY LOW BIRTH WEIGHT INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
Y.C. Huang et al., "ASSOCIATION OF FUNGAL COLONIZATION AND INVASIVE DISEASE IN VERY-LOW-BIRTH-WEIGHT INFANTS", The Pediatric infectious disease journal, 17(9), 1998, pp. 819-822

Abstract

Background. Fungi are common pathogens of nosocomial infections in the very low birth weight (VLBW) infants. The purpose of this study was to investigate the fungal colonization rate in VLBW infants and the association between fungal colonization and systemic fungal diseases. Materials. Between January 1, 1996, and December 31, 1996, 116 infants with birth weight <1500 g admitted to the neonatal intensive care unit of Chang Gung Children's Hospital in the first day of life were included in this prospective study. Methods. Cultures from oropharynx, rectum, skin (groin and axilla), bag urine and endotracheal aspirates were obtained in the first 24 h after birth and weekly thereafter throughout their neonatal intensive care unit stay. Medical records were reviewed weekly. Results. Fungal colonization was detected in 25 infants, among whom 17 infants developed colonization by 2 weeks of life. Candidaalbicans (61%) and Candida parapsilosis (29%) were the 2 most common organisms. The rectum (76%) was the most frequent site of colonization. Factors significantly associated with colonization were prolonged administration of antibiotic therapy, parenteral nutrition and intralipid emulsion. Three of 116 infants developed fungemia, The association between colonization and subsequent fungemia was demonstrated in 1 infant, representing 4% of colonized infants. Conclusion. Fungal colonization was detected in one-fifth of VLBW infants and represents a risk factor for fungemia, Because disease occurred in the absence of apparentcolonization, factors other than colonization may contribute to invasive candidiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:12:07