Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FUNCTIONAL IMAGING OF THE BRAIN IN THE EVALUATION OF DRUG RESPONSE AND ITS APPLICATION TO THE STUDY OF AGING
Autore:
BRYANT CA; JACKSON SHD;
Indirizzi:
UNIV LONDON KINGS COLL,SCH MED & DENT,DEPT HLTH CARE ELDERLY,CLIN AGERES UNIT,BESSEMER RD LONDON SE5 9PJ ENGLAND
Titolo Testata:
Drugs & aging
fascicolo: 3, volume: 13, anno: 1998,
pagine: 211 - 222
SICI:
1170-229X(1998)13:3<211:FIOTBI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; D2-DOPAMINE RECEPTOR OCCUPANCY; NAIVE SCHIZOPHRENIC-PATIENTS; D-2 DOPAMINE-RECEPTORS; HUMAN WORKING-MEMORY; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CONTROLLED TRIAL; C-11 RACLOPRIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
111
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Bryant e S.H.D. Jackson, "FUNCTIONAL IMAGING OF THE BRAIN IN THE EVALUATION OF DRUG RESPONSE AND ITS APPLICATION TO THE STUDY OF AGING", Drugs & aging, 13(3), 1998, pp. 211-222

Abstract

Functional neuroimaging techniques including single photon emission computerised tomography (SPECT), positron emission tomography (PET) andfunctional magnetic resonance imaging (FMRI) can provide insight intothe functional connectivity of the human brain in both health and disease, including the effects of aging and drugs on brain function. Neuroimaging measurement techniques can either be direct, using radio-specific ligands, or indirect, using the neurophysiological consequences of pharmacological interventions. Both approaches can be combined with sensorimotor or cognitive activation to examine the interaction between the targeted receptor function and the sensorimotor or cognitive process implicit in the study design. Using radionuclides, PET can provide absolute measurement of cerebral blood flow to regions of interest and can measure changes in cerebral metabolism using labelled fluorodeoxyglucose. PET offered the first opportunity to image brain activationcaused by a variety of stimuli and hence to measure the effect of drugs on brain activation. PET also enables the study of drug dispositionwithin the brain. SPECT has been used to study relative changes in cerebral blood flow associated with disease processes and also receptor occupancy. FMRI, by contrast, does not involve ionising radiation and has better spatial and temporal resolution. It is still a relatively new technique and limited by its ability to only measure haemodynamic changes through the blood oxygen level-dependent (BOLD) signal. The effects of aging on drug responsiveness and the effects of drug treatmentof diseases associated with old age are relatively unexplored areas of functional neuroimaging research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:07