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Titolo:
NEUROFIBROSARCOMA-DERIVED SCHWANN-CELLS OVEREXPRESS PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTORS AND ARE INDUCED TO PROLIFERATE BY PDGF BE
Autore:
BADACHE A; DEVRIES GH;
Indirizzi:
FRIEDRICH MIESCHER INST,POB 2543 CH-4002 BASEL SWITZERLAND LOYOLA UNIV,MED CTR,DEPT CELL BIOL NEUROBIOL & ANAT CHICAGO IL 60611 VET AFFAIRS EDWARD HINES JR HOSP HINES IL 00000
Titolo Testata:
Journal of cellular physiology
fascicolo: 2, volume: 177, anno: 1998,
pagine: 334 - 342
SICI:
0021-9541(1998)177:2<334:NSOPG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBROMATOSIS TYPE-1 GENE; NERVE SHEATH TUMORS; PERIPHERAL-NERVE; ALPHA-RECEPTORS; BETA-RECEPTORS; SCIATIC-NERVE; IDENTIFICATION; NEUREGULINS; EXPRESSION; DELETIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A. Badache e G.H. Devries, "NEUROFIBROSARCOMA-DERIVED SCHWANN-CELLS OVEREXPRESS PLATELET-DERIVED GROWTH-FACTOR (PDGF) RECEPTORS AND ARE INDUCED TO PROLIFERATE BY PDGF BE", Journal of cellular physiology, 177(2), 1998, pp. 334-342

Abstract

Neurofibromatosis type 1 (NF1) is characterized by the formation of neurofibromas, benign tumors of the peripheral nerve consisting essentially of Schwann cells, which can sometimes turn malignant to form neurofibrosarcomas. The mechanism of progression toward a malignant phenotype remains largely unknown. In this report, we show that platelet-derived growth factor (PDGF) BB, and to a lesser extent fibroblast growthfactor 2, are mitogenic for two neurofibrosarcoma-derived Schwann cell lines, but not for a Schwann cell line derived from a schwannoma (from a non-NF1 patient) or for transformed rat Schwann cells. Levels of expression of both PDGF receptor alpha and beta are significantly increased in the two neurofibrosarcoma-derived cell lines compared to the non-NF1 Schwann cell lines. The level of tyrosyl-phosphorylated PDGF receptor beta is strongly increased upon stimulation by PDGF BE. In comparison, only modest levels of tyrosyl-phosphorylated PDGF receptor alpha are observed, upon stimulation by PDGF AA or PDGF BE. Accordingly,PDGF AA is only a weak mitogen for the neurofibrosarcoma-derived cells by comparison to PDGF BB. These results indicate that the mitogenic effect of PDGF BE for the neurofibrosarcoma-derived Schwann cell linesis primarily transduced by PDGF receptor beta. Neu differentiation factor beta, a potent mitogen for normal Schwann cells, was unable to stimulate proliferation of the transformed Schwann cell lines, due to a dramatic downregulation of the erbB3 receptor. Therefore, aberrant expression of growth factor receptors by Schwann cells, such as the PDGF receptors, could represent an important step in the process leading toSchwann cell hyperplasia in NF1. J. Cell. Physiol. 177:334-342, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:32:50