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Titolo:
PERIPHERAL SEROTONIN MEASURES IN PREPUBERTAL PSYCHIATRIC-INPATIENTS AND NORMAL-CHILDREN - ASSOCIATIONS WITH SUICIDAL-BEHAVIOR AND ITS RISK-FACTORS
Autore:
PFEFFER CR; MCBRIDE PA; ANDERSON GM; KAKUMA T; FENSTERHEIM L; KHAIT V;
Indirizzi:
CORNELL UNIV,NEW YORK HOSP,MED CTR,WESTCHESTER DIV,21 BLOOMINGDALE RDWHITE PLAINS NY 10605 CORNELL UNIV,COLL MED,DEPT PSYCHIAT WHITE PLAINS NY 00000 YALE UNIV,SCH MED,DEPT LAB MED NEW HAVEN CT 06510 CORNELL UNIV,NEW YORK HOSP,MED CTR,WESTCHESTER DIV WHITE PLAINS NY 10605 NEW YORK HOSP NEW YORK NY 10021
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 44, anno: 1998,
pagine: 568 - 577
SICI:
0006-3223(1998)44:7<568:PSMIPP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHOLE-BLOOD SEROTONIN; DEFICIT HYPERACTIVITY DISORDER; MAJOR DEPRESSIVE DISORDER; PLATELET SEROTONIN; ENDOGENOUS-DEPRESSION; PERSONALITY-DISORDERS; IMIPRAMINE BINDING; 5-HT2A RECEPTOR; VIOLENT SUICIDE; PLASMA;
Keywords:
SEROTONIN MEASURES; PREPUBERTAL SUICIDAL BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Pfeffer et al., "PERIPHERAL SEROTONIN MEASURES IN PREPUBERTAL PSYCHIATRIC-INPATIENTS AND NORMAL-CHILDREN - ASSOCIATIONS WITH SUICIDAL-BEHAVIOR AND ITS RISK-FACTORS", Biological psychiatry, 44(7), 1998, pp. 568-577

Abstract

Background: This study reports relationships between suicidal behavior and its risk factors in prepubertal children and whole blood and platelet serotonin-related measures. Methods: Seventy-five prepubertal psychiatric inpatients including 23 (30.7%) nonsuicidal, 32 (42.7%) withsuicidal ideation, and 20 (26.6%) with a suicide attempt were compared to 35 normal prepubertal controls with regard to platelet serotonin content serotonin-amplified platelet aggregation, and whole blood tryptophan. Results: Mean whole blood tryptophan content was significantlylower among inpatient children,vith a recent suicide attempt than among normal controls or inpatients,vith suicidal ideation (F = 3.94, df = 3.54, p less than or equal to .01). Inpatient children with a mood disorder had significantly higher platelet serotonin content than inpatients,without a mood disorder (F = 3.86, df = 2,80, p less than or equal to .03), Racial/ethnic differences were also observed for inpatients and normal controls, with whites having significantly lon er levels of platelet serotonin (expressed as ng/mL blood or ng/10(9) platelets)than blacks or Latinos. Blacks had significantly higher levels of whole blood tryptophan than other racial/ethnic groups. Conclusions: The results suggest that whole blood tryptophan and platelet serotonin content should be studied for their predictive validity as risk factors for suicidal behavior in youth while controlling for racial/ethnic differences. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 22/01/20 alle ore 12:47:16