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Titolo:
IMAGING OF THE SEROTONERGIC SYSTEM - INTERACTIONS OF NEUROANATOMICAL AND FUNCTIONAL ABNORMALITIES OF DEPRESSION
Autore:
STALEY JK; MALISON RT; INNIS RB;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,950 CAMPBELL AVE, W HAVEN CT 06516 VET AFFAIRS MED CTR W HAVEN CT 06516 CONNECTICUT MENTAL HLTH CTR NEW HAVEN CT 00000
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 44, anno: 1998,
pagine: 534 - 549
SICI:
0006-3223(1998)44:7<534:IOTSS->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; TRITIATED IMIPRAMINE BINDING; POSTMORTEM HUMAN BRAIN; LIVING HUMAN-BRAIN; SUICIDE VICTIMS; IN-VIVO; MAJOR DEPRESSION; FRONTAL-CORTEX; RECEPTOR-BINDING;
Keywords:
DEPRESSION; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SEROTONIN TRANSPORTER; SEROTONIN RECEPTORS; TRYPTOPHAN HYDROXYLASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
145
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Staley et al., "IMAGING OF THE SEROTONERGIC SYSTEM - INTERACTIONS OF NEUROANATOMICAL AND FUNCTIONAL ABNORMALITIES OF DEPRESSION", Biological psychiatry, 44(7), 1998, pp. 534-549

Abstract

For nearly three decades, evidence supporting a role for aberrant serotonergic function in the pathogenesis of depression has accumulated; however, only recently have methodologies and radiotracers suitable for in vivo clinical assessment of depression become available. To dare,only a few neurochemical imaging studies have been performed in actively depressed subjects. A preliminary study using single photon emission computed tomography (SPECT) has demonstrated decreased levels of serotonin (5-HT) transporters in the midbrain regions of subjects with major depression. Analysis of the 5-HT2 receptor using positron emission tomography (PET) has suggested that this, receptor may not be altered significantly in the depressed brain but may increase in response toantidepressant treatment. These findings are supported by studies in secondary ''poststroke'' depression that have shown that elevations in5-HT2 receptor density correlated with the alleviation of symptoms ofdepressed mood. With the rapid development of novel PET and SPECT radiotracers, future studies of the serotonergic system that evaluate presynaptic (5-HT transporter) and postsynaptic (5-HT1A and 5-HT2A receptors) markers and the interaction of synaptic levels of 5-HT with thesesites will make profound contributions to the understanding of the role of the serotonergic synapse in the pathophysiology of depression. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 20/01/20 alle ore 10:17:38