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Titolo:
ALTERATIONS IN PULMONARY SURFACTANT COMPOSITION AND ACTIVITY AFTER EXPERIMENTAL LUNG TRANSPLANTATION
Autore:
VELDHUIZEN RAW; LEE J; SANDLER D; HULL W; WHITSETT JA; LEWIS J; POSSMAYER F; NOVICK RJ;
Indirizzi:
UNIV WESTERN ONTARIO,DEPT OBSTET & GYNAECOL,ROOM 845,339 WINDERMERE RD LONDON N6A 5A5 ONTARIO CANADA UNIV WESTERN ONTARIO,DEPT BIOCHEM LONDON N6A 5A5 ONTARIO CANADA UNIV WESTERN ONTARIO,DEPT MED LONDON N6A 5A5 ONTARIO CANADA UNIV WESTERN ONTARIO,MRC,FETAL & NEONATAL HLTH & DEV GRP LONDON N6A 5A5 ONTARIO CANADA UNIV WESTERN ONTARIO,UNIV HOSP,DIV CARDIOVASC THORAC SURG LONDON N6A 5A5 ONTARIO CANADA UNIV CINCINNATI,COLL MED,DEPT PEDIAT CINCINNATI OH 45221
Titolo Testata:
The American review of respiratory disease
fascicolo: 1, volume: 148, anno: 1993,
pagine: 208 - 215
SICI:
0003-0805(1993)148:1<208:AIPSCA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; BRONCHOALVEOLAR LAVAGE; ALVEOLAR SURFACTANT; EURO-COLLINS; UW SOLUTION; PRESERVATION; PROTEINS; PATHOGENESIS; METABOLISM; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.A.W. Veldhuizen et al., "ALTERATIONS IN PULMONARY SURFACTANT COMPOSITION AND ACTIVITY AFTER EXPERIMENTAL LUNG TRANSPLANTATION", The American review of respiratory disease, 148(1), 1993, pp. 208-215

Abstract

Pulmonary surfactant facilitates breathing by reducing the surface tension at the air/liquid interface. We examined the effect of experimental lung transplantation on the phospholipid pool sizes of alveolar surfactant large and small aggregates, the composition of the large aggregates, the surface tension-reducing ability of lipid extract surfactant, and the leakage of serum proteins into the lung. A double-lung block from the donor animal was stored for 2 or 12 h after perfusion witheither Euro-Collins solution or University of Wisconsin solution. Theright donor lung was lavaged immediately after the storage period to determine the effects of storage on pulmonary surfactant. The left donor lung was transplanted. The recipient animal, containing its own native right lung and the transplanted left lung, was reperfused for 6 h. After the reperfusion period, the transplanted left lung and the native right lung were lavaged. After an ischemic time of 12 h, impaired gas exchange was observed in the transplanted lung as well as the native lung during the 6 h of reperfusion. This impaired gas exchange was associated with several significant changes in pulmonary surfactant: (1) total serum protein in the lung lavage was increased, (2) the small to large surfactant aggregate ratio was increased, (3) sphingomyelin content was increased and phosphatidylglycerol content was decreased inlarge aggregates, and (4) the surfactant-associated protein. A content was decreased in large aggregates. No significant differences were observed between the results obtained with Euro-Collins and University of Wisconsin solutions. We conclude that prolonged storage of the donor lung before transplantation results in ischemic damage that producesan increase in potential surfactant inhibitors and can alter the small to large surfactant aggregate ratio after lung transplantation. These alterations in pulmonary surfactant resemble those observed in many adult respiratory distress syndrome types of injuries. We conclude that surfactant supplementation in lung transplantation should be investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:09:10