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Titolo:
MEASUREMENT OF SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND ITS CLINICAL-APPLICATION FOR ESTIMATING THE ACTIVITY OF GRANULOMA-FORMATION IN SARCOIDOSIS
Autore:
IYONAGA K; SUGA M; ICHIYASU H; YAMAMOTO T; HIRAGA Y; ANDO M;
Indirizzi:
KUMAMOTO UNIV,DEPT INTERNAL MED 1,SCH MED,1-1-1 HONJO KUMAMOTO 8600811 JAPAN SAPPORO HOSP,HOKKAIDO RAILWAYS CO SAPPORO HOKKAIDO JAPAN
Titolo Testata:
Sarcoidosis vasculitis and diffuse lung diseases
fascicolo: 2, volume: 15, anno: 1998,
pagine: 165 - 172
SICI:
1124-0490(1998)15:2<165:MOSMCP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; BRONCHOALVEOLAR LAVAGE FLUID; BLOOD MONONUCLEAR LEUKOCYTES; CONVERTING-ENZYME; EXPRESSION; MCP-1; MACROPHAGES; CELLS;
Keywords:
SERUM MCP-1; ACE; SARCOIDOSIS; GRANULOMA FORMATION; DISEASE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Iyonaga et al., "MEASUREMENT OF SERUM MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND ITS CLINICAL-APPLICATION FOR ESTIMATING THE ACTIVITY OF GRANULOMA-FORMATION IN SARCOIDOSIS", Sarcoidosis vasculitis and diffuse lung diseases, 15(2), 1998, pp. 165-172

Abstract

Background and aim of the work: The role of monocyte chemoattractant protein-1 (MCP-1) in bronchoalveolar lavage fluids from sarcoidosis patients was previously reported. To study the role of MCP-1, we evaluated the serum MCP-1 and its clinical significance in sarcoidosis. Methods: The serum MCP-1 level was measured in 47 patients with sarcoidosisand 10 normal healthy controls with the use of an enzyme-linked immunosorbent assay, The localization and mRNA expression of MCP-1 in sarcoid lymphnodes were evaluated by an immunohistochemical method using ananti-MCP-l monoclonal antibody and an in situ hybridization techniqueto determine the cellular source(s) of MCP-I. Results: Serum MCP-1 levels were significantly elevated in the sarcoidosis patients compared with the healthy controls (698.3+/-101.9 vs. less than 39 pg/ml, p < 0.001). A comparison of the patients' serum MCP-1 levels among standardradiographic stages revealed that the serum MCP-I was significantly higher in early stages: stage 0 vs. III, and stage I vs. II. In addition, the serum MCP-I levels were significantly correlated with the serumangiotensin converting enzyme levels (r = 0.539, p = 0.0006). MCP-I expression was detected in macrophages peripheral to the epithelioid granuloma in sarcoid lymphnodes, by both immunohistochemistry and ill situ hybridization. Conclusions: These data suggest that MCP-1 may be expressed by the macrophages in the granuloma throughout the body, and that the measurement of serum MCP-I levels may have clinical value as an indicator in estimating the activity of granuloma formation throughout the body in sarcoidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:48:42