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Titolo:
INVOLVEMENT OF MULTIPLE BIOTRANSFORMATION PROCESSES IN THE METABOLIC ELIMINATION OF TESTOSTERONE BY JUVENILE AND ADULT FATHEAD MINNOWS (PIMEPHALES-PROMELAS)
Autore:
PARKS LG; LEBLANC GA;
Indirizzi:
N CAROLINA STATE UNIV,DEPT TOXICOL,BOX 7633 RALEIGH NC 27695 N CAROLINA STATE UNIV,DEPT TOXICOL RALEIGH NC 27695
Titolo Testata:
General and comparative endocrinology (Print)
fascicolo: 1, volume: 112, anno: 1998,
pagine: 69 - 79
SICI:
0016-6480(1998)112:1<69:IOMBPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLOUNDER PSEUDOPLEURONECTES-AMERICANUS; CATOSTOMUS-COMMERSONI POPULATION; TROUT SALMO-GAIRDNERI; PLASMA STEROID-LEVELS; RAINBOW-TROUT; MARINE TELEOST; CYTOCHROME-P-450 ISOZYMES; STENOTOMUS-CHRYSOPS; INVITRO METABOLISM; SEX-DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
L.G. Parks e G.A. Leblanc, "INVOLVEMENT OF MULTIPLE BIOTRANSFORMATION PROCESSES IN THE METABOLIC ELIMINATION OF TESTOSTERONE BY JUVENILE AND ADULT FATHEAD MINNOWS (PIMEPHALES-PROMELAS)", General and comparative endocrinology (Print), 112(1), 1998, pp. 69-79

Abstract

Steroid hormone metabolic clearance pathways are susceptible to induction and suppression resulting from exposure to many xenobiotics. These biochemical effects have the potential to alter steroid hormone homeostasis and, ultimately, steroid hormone-dependent processes such as growth, development, and reproduction. In this study, the metabolic clearance of 17 beta-hydroxy-4-androsten-3-one (testosterone) by adult male, adult female, and juvenile fathead minnows (Pimephales promelas) was evaluated. Individual elimination metabolites were identified and rates of metabolite elimination were quantified. Fathead minnows produced a variety of testosterone metabolites including oxide-reduced, hydroxylated, and conjugated derivatives. Metabolites identified by TLC/GC/MS included 4-androstene-3,17-dione (androstenedione), 17 beta-hydroxy-5 alpha-androstan-3-one (5 alpha-dihydrotestosterone), 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-androstanediol), 5 alpha-androstane-3 beta,17 beta-diol (3 beta-androstanediol), 17 beta-hydroxy-4-androstene-3,11-dione (11-ketotestosterone), 16 beta-hydroxy-4-androsten-3-one (6 beta-hydroxytestosterone), and 6 beta-hydroxy-4-androsten-3-one(6 beta-hydroxytestosterone). Testosterone and its metabolites were eliminated in both free and conjugated form. Adult male, adult female, and juvenile fathead minnows eliminated the same profile of testosterone metabolites. However, adult females eliminated androstanediols at asignificantly greater rate than did males, and juvenile fish eliminated nearly all testosterone metabolites at greater weight-normalized rates than did adults. These results demonstrate that fathead minnows extensively metabolize testosterone leading to its elimination and provide the foundation upon which the effects of xenobiotics on testosterone metabolism can be assessed. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:20:42