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Titolo:
MANNOSE-BINDING LECTIN PLASMA-LEVELS AND GENE POLYMORPHISMS IN PLASMODIUM-FALCIPARUM MALARIA
Autore:
LUTY AJF; KUN JFJ; KREMSNER PG;
Indirizzi:
UNIV TUBINGEN,INST TROP MED,SEKT HUMANPARASITOL,DEPT PARASITOL,WILHELMSTR 27 D-72074 TUBINGEN GERMANY ALBERT SCHWEITZER HOSP,RES UNIT LAMBARENE GABON
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 178, anno: 1998,
pagine: 1221 - 1224
SICI:
0022-1899(1998)178:4<1221:MLPAGP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A.J.F. Luty et al., "MANNOSE-BINDING LECTIN PLASMA-LEVELS AND GENE POLYMORPHISMS IN PLASMODIUM-FALCIPARUM MALARIA", The Journal of infectious diseases, 178(4), 1998, pp. 1221-1224

Abstract

The contribution of mannose-binding lectin (MBL) to protection from malaria was assessed by comparing plasma concentrations of MBL and the frequency of MBL gene polymorphisms in groups of Gabonese children participating in a prospective study of severe and mild malaria due to infection with Plasmodium falciparum. At admission, a higher proportion of patients with severe malaria had a low level of MBL compared with subjects with mild malaria (0.35 vs. 0.19, P = .02). Two mutations in codons 54 and 57 of the MBL gene were detected. They were present at higher frequency in those with severe malaria (0.45 vs. 0.31, P = .04). These results suggest that deficient innate immune responses, in the form of low MBL levels, may be a risk factor for severe malaria in someyoung children who lack well-developed, clinically protective acquired immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:04:53