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Titolo:
SINGLE-DOSE TROPISETRON FOR PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER BREAST SURGERY
Autore:
CHAN MTV; CHUI PT; HO WS; KING WWK;
Indirizzi:
CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT ANAESTHESIA & INTENS CARE SHATIN NEW TERRITORIES HONG KONG CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT SURG SHATIN NEW TERRITORIES HONG KONG
Titolo Testata:
Anesthesia and analgesia
fascicolo: 4, volume: 87, anno: 1998,
pagine: 931 - 935
SICI:
0003-2999(1998)87:4<931:STFPPN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC ANTIEMETIC THERAPY; GYNECOLOGICAL SURGERY; DOUBLE-BLIND; NITROUS-OXIDE; METOCLOPRAMIDE; ANESTHESIA; EFFICACY; PLACEBO; CHEMOTHERAPY; METAANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.T.V. Chan et al., "SINGLE-DOSE TROPISETRON FOR PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER BREAST SURGERY", Anesthesia and analgesia, 87(4), 1998, pp. 931-935

Abstract

In this randomized, double-blind, placebo-controlled study, we compared the efficacy of tropisetron 5 mg with tropisetron 2 mg for the prevention of postoperative nausea and vomiting (PONV) after breast surgery. One hundred forty-eight female patients were randomized to receive either tropisetron 5 mg (n = 49), tropisetron 2 mg (n = 49), or saline(n = 50) before the induction of anesthesia with thiopental and morphine. Anesthesia was maintained with nitrous oxide and isoflurane. Postoperative analgesia was provided by patient-controlled analgesia with IV morphine. The incidence of PONV, the pain score, and the analgesic requirement were recorded for 48 h. There was no difference among groups in patient characteristics, risk factors for PONV, morphine consumption or side effects. During the first 6 h postoperatively, the incidence of PONV after tropisetron 2 mg and 5 mg were similar and were superior to placebo (P < 0.001). After 6 h, the incidence of PONV increased significantly in patients who had received tropisetron 2 mg (P = 0.01) and was greater than that in patients who had received tropisetron 5 mg (P = 0.001). We conclude that single-dose tropisetron 5 mg is more effective than tropisetron 2 mg in the prevention of PONV after breast surgery. Implications: Breast surgery is associated with a high incidence of postoperative nausea and vomiting. A single dose of IV tropisetron 5 mg is well tolerated and decreases the number of vomiting andnausea episodes after surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:29:04