Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
METAANALYSIS OF STREPTOKINASE AND HEPARIN IN DEEP-VEIN THROMBOSIS
Autore:
NG CM; RIVERA JO;
Indirizzi:
UNIV N CAROLINA,SCH PHARM,DEPT DRUG DELIVERY & DISPOSIT,BEARD HALL,CB7360 CHAPEL HILL NC 27599 GLAXO WELLCOME INC RES TRIANGLE PK NC 27709 BEN TAUB GEN HOSP HOUSTON TX 77030 UNIV TEXAS,PHARM PROGRAM EL PASO TX 79968
Titolo Testata:
American journal of health-system pharmacy
fascicolo: 19, volume: 55, anno: 1998,
pagine: 1995 - 2001
SICI:
1079-2082(1998)55:19<1995:MOSAHI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL VENOUS THROMBOSIS; LONG-TERM SEQUELAE; MYOCARDIAL-INFARCTION; THROMBOLYTIC THERAPY; RANDOMIZED TRIALS; METAANALYSIS;
Keywords:
ANTICOAGULANTS; CLINICAL STUDIES; DOSAGE SCHEDULES; DRUG COMPARISONS; DRUGS; CLINICAL EFFECTIVENESS; HEMORRHAGE; HEPARIN; STREPTOKINASE; THROMBOLYTIC AGENTS; THROMBOPHLEBITIS; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Ng e J.O. Rivera, "METAANALYSIS OF STREPTOKINASE AND HEPARIN IN DEEP-VEIN THROMBOSIS", American journal of health-system pharmacy, 55(19), 1998, pp. 1995-2001

Abstract

The efficacy and safety of streptokinase and heparin in deep vein thrombosis (DVT) were compared in a meta-analysis. Randomized trials in which streptokinase (followed by heparin) and heparin alone were compared in treating phlebographically documented acute DVT were identified from MEDLINE and other sources for a meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) based on the legit method were computed for each study. A fixed-effect model was used to combine the study results, enabling differences between streptokinase recipients and recipients of heparin alone to be expressed as summary ORs with 95% CIs. Significantly more streptokinase recipients achieved thrombolysis than recipients of heparin alone (summary OR, 6.24; 95% CI, 3.62 to 10.78). One study was identified as an outlier and excluded from the analysis. The meta-analysis then showed that streptokinase recipients were significantly less likely to have postthrombotic changes (summary OR, 0.40; 95% CI, 0.18 to 0.88) and postphlebitic changes (summary OR, 0.32; 95% CI, 0.12 to 0.86) in phlebographic evaluation. The frequency ofmajor bleeding was significantly higher among streptokinase recipients than recipients of heparin alone (summary OR, 3.78; 95% CI, 1.26 to 11.32). A meta-analysis showed that, compared with heparin alone, streptokinase therapy for DVT was associated with significantly more frequent thrombolysis and major bleeding; after exclusion of one outlying study, analysis showed that streptokinase therapy was associated less frequently than heparin alone with postthrombotic changes (assessed by phlebographic evaluation) and postphlebitic syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:34:31