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Titolo:
HEMODYNAMIC-EFFECTS OF A SINGLE INTRAVENOUS APPLICATION OF PROSTAGLANDIN E-1 ON PATIENTS WITH CHRONIC HEART-FAILURE NYHA CLASS II III/
Autore:
SCHRADER N; ERBEL R; WITTLICH N; BANAIE M; GSCHOSSMANN J; RINK C; FUCHS JB; DAGRES N; MOHRKAHALY SA; MEYER J;
Indirizzi:
MARTIN LUTHER KRANKENHAUS WATTENSCHEID,INNERE MED ABT,VOEDESTR 79 D-44866 BOCHUM GERMANY UNIV MAINZ,MED KLIN & POLIKLIN 2 D-55131 MAINZ GERMANY
Titolo Testata:
Zeitschrift fur Kardiologie
fascicolo: 9, volume: 87, anno: 1998,
pagine: 683 -
SICI:
0300-5860(1998)87:9<683:HOASIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR FAILURE; INFUSION; DISEASE; INJURY; DOG;
Keywords:
PROSTAGLANDIN E-1 (PGE(1)); CONGESTIVE HEART FAILURE; HEMODYNAMIC EFFECTS; CONTRACTILITY; PERIPHERAL ARTERY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
N. Schrader et al., "HEMODYNAMIC-EFFECTS OF A SINGLE INTRAVENOUS APPLICATION OF PROSTAGLANDIN E-1 ON PATIENTS WITH CHRONIC HEART-FAILURE NYHA CLASS II III/", Zeitschrift fur Kardiologie, 87(9), 1998, pp. 683

Abstract

We investigated the hemodynamic effects of a single infusion of PGE(1) (60 mu g infused over a period of 2 h - this is the single dose usedin courses of treatment for peripheral occlusive arterial disease) inpatients with chronic heart failure NYHA class II-III. The ejection fraction of these patients was < 55 %, their average age was 58.4 years(standard deviation 10 years), and their condition was stable. Nineteen of the patients had coronary heart disease and one patient had myocarditis. The hemodynamic data were obtained invasively by catheterization of the right and left heart. Blood pressure and pulse rate were measured manually. Intravenous infusion of 60 mu g PGE(1) over a period of 2 hours did not significantly alter contractility or hemodynamics. Dp/dtmax, dp/dtmax/p, and dp/dt DP40, which are parameters of left ventricular contractility,determined with the aid of a catheter-tip manometer, did not differ significantly over time from those in the placebocontrol group. Similarly, the other data furnished no evidence that administration of PGE(1) had any hemodynamic or myocardial effects. Hence, it is reasonable to state that it is safe to administer PGE(1) to patients with peripheral occlusive arterial disease.

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Documento generato il 02/12/20 alle ore 07:26:35