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Titolo:
OPIATE RECEPTOR AVIDITY IS REDUCED IN NONMOTOR IMPAIRED MPTP-LESIONEDRHESUS-MONKEYS
Autore:
COHEN RM; CARSON RE; AIGNER TG; DOUDET DJ;
Indirizzi:
NIMH,CEREBRAL METAB LAB,BLDG 36,ROOM 1A05,36 CONVENT DR MSC 4030 BETHESDA MD 20892 NIH,PET DEPT,CTR CLIN BETHESDA MD 20892 NIMH,NEUROPSYCHOL LAB BETHESDA MD 20892
Titolo Testata:
Brain research
fascicolo: 2, volume: 806, anno: 1998,
pagine: 292 - 296
SICI:
0006-8993(1998)806:2<292:ORAIRI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BASAL GANGLIA; PARKINSONS-DISEASE; HUMAN-BRAIN; ENKEPHALIN; IMMUNOREACTIVITY; EXPOSURE; MODEL; DOPA;
Keywords:
PARKINSONS DISEASE; NEURODEGENERATION; 6-DEOXY-6-BETA-[F-18]FLUORONALTREXONE; POSITRON EMISSION TOMOGRAPHY; BASAL GANGLIA; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Cohen et al., "OPIATE RECEPTOR AVIDITY IS REDUCED IN NONMOTOR IMPAIRED MPTP-LESIONEDRHESUS-MONKEYS", Brain research, 806(2), 1998, pp. 292-296

Abstract

Opiate receptor avidity, roughly equivalent to the ratio of unoccupied receptor density to the receptor dissociation constant (B-max'/K-D),was measured in four MPTP thyl-4-phenyl-1,2,3,6-tetrahydropyridine)-lesioned rhesus monkeys and nine normal controls with positron emissiontomography (PET) and 6-deoxy-6-beta-[F-18]fluoronaltrexone (cyclofoxy, CF), a mu- and kappa-opiate receptor antagonist. Although the MPTP-lesioned monkeys were dopamine deficient as measured with [F-18]-L-fluorodopa ([F-18]-DOPA) and PET [Doudet et al., 6-[F-18]-L-DOPA imaging of the dopamine neostriatal system in normal and clinically normal-MPTP-treated rhesus monkeys, Exp. Brain Res. 78 (1989) 69-80], they had clinically recovered from the acute motor effects of MPTP exposure. Opiate receptor avidity was found to be reduced by 30-35% in the opiate-receptor rich areas of caudate, anterior putamen, thalamus, and amygdalaof the MPTP-lesioned animals. The results suggest that opiate pathways make a significant contribution to the adjustment of cortico-striatal-thalamic pathway activity and thereby to behavior in rhesus monkeys following dopamine loss. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 21/09/20 alle ore 01:54:35