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Titolo:
ORIGIN OF NORADRENERGIC AFFERENTS TO THE SHELL SUBREGION OF THE NUCLEUS-ACCUMBENS - ANTEROGRADE AND RETROGRADE TRACT-TRACING STUDIES IN THERAT
Autore:
DELFS JM; ZHU Y; DRUHAN JP; ASTONJONES GS;
Indirizzi:
UNIV PENN,LAB NEUROMODULAT & BEHAV,DEPT PSYCHIAT,SCH MED,VET AFFAIRS MED CTR,UNIV & WOODLAND AVE PHILADELPHIA PA 19104 UNIV PENN,LAB NEUROMODULAT & BEHAV,DEPT PSYCHIAT,SCH MED,VET AFFAIRS MED CTR PHILADELPHIA PA 19104
Titolo Testata:
Brain research
fascicolo: 2, volume: 806, anno: 1998,
pagine: 127 - 140
SICI:
0006-8993(1998)806:2<127:OONATT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-BETA-HYDROXYLASE; GAMMA-AMINOBUTYRIC-ACID; VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; B SUBUNIT CTB; OPIATE WITHDRAWAL; LOCUS COERULEUS; CATECHOLAMINERGIC NEURONS; IONTOPHORETIC APPLICATION; HORSERADISH-PEROXIDASE;
Keywords:
NUCLEUS TRACTUS SOLITARIUS; MEDULLA; NORADRENERGIC; VENTRAL STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
86
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Delfs et al., "ORIGIN OF NORADRENERGIC AFFERENTS TO THE SHELL SUBREGION OF THE NUCLEUS-ACCUMBENS - ANTEROGRADE AND RETROGRADE TRACT-TRACING STUDIES IN THERAT", Brain research, 806(2), 1998, pp. 127-140

Abstract

The nucleus accumbens (NAcc) can be subdivided into 'core' and 'shell' based on anatomical connections and histochemical markers. Previous studies have demonstrated dopamine-beta-hydroxylase immunoreactive (DBH-ir) fibers in the NAcc shell, but the source of these noradrenergic (NE) afferents has not been determined. Therefore, we have investigated in detail the anatomy of NE afferents to this subregion. Dual immunohistochemistry for DBH and substance P demonstrated numerous DBH-ir fibers in the caudal NAcc shell. Neurons projecting to the NAcc were identified with Fluoro-Gold (FG) or cholera toxin B (CTb) retrograde tracing and tyrosine hydroxylase (TH) immunohistochemistry. Single- and double-labeled neurons were observed in the A2 and Al NE cell groups following FG injections into the caudal NAcc shell. Numerous FG and CTb single-labeled neurons were found in the rostral locus coeruleus (LC), subcoeruleus and pericoerulear dendritic region, with an occasional double-labeled neuron in the LC. Few labeled neurons were seen in the brainstem after FG injections into the NAcc core, consistent with the lack of DBH-ir in this subterritory. To confirm these results, injections of Phaseolus vulgaris leucoagglutinin or biotinylated dextran amine were made into the LC or nucleus tractus solitarius (NTS). Virtually no labeled fibers were observed in the NAcc following injections into central LC. However, fibers were observed in the NAcc shell after injections in the NTS, These results indicate that the primary source(s) ofNE afferents to the NAcc shell is the A2 region of the NTS, with lesser contributions from Al and LC. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:31:41