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Titolo:
PUPILLOMETRIC CHANGES DURING GRADUAL OPIATE DETOXIFICATION CORRELATE WITH CHANGES IN SYMPTOMS OF OPIATE WITHDRAWAL AS MEASURED BY THE WEAK OPIATE WITHDRAWAL SCALE
Autore:
ROSSE RB; JOHRI S; GOEL M; RAHMAN F; JAWOR KA; DEUTSCH SI;
Indirizzi:
DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV,ROOM 3A154-116A,50 IRVING ST NW WASHINGTON DC 20422 DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV WASHINGTON DC 20422 GEORGETOWN UNIV,SCH MED,DEPT PSYCHIAT WASHINGTON DC 00000
Titolo Testata:
Clinical neuropharmacology
fascicolo: 5, volume: 21, anno: 1998,
pagine: 312 - 315
SICI:
0362-5664(1998)21:5<312:PCDGOD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAINTENANCE; CLONIDINE;
Keywords:
PUPILLOMETRY; METHADONE; PUPIL SIZE; OPIATE DEPENDENCE; CRAVING; WITHDRAWAL SYMPTOMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Rosse et al., "PUPILLOMETRIC CHANGES DURING GRADUAL OPIATE DETOXIFICATION CORRELATE WITH CHANGES IN SYMPTOMS OF OPIATE WITHDRAWAL AS MEASURED BY THE WEAK OPIATE WITHDRAWAL SCALE", Clinical neuropharmacology, 21(5), 1998, pp. 312-315

Abstract

The relationship between pupil size and subjective symptoms of opiatewithdrawal during gradual opiate agonist detoxification has not yet been studied: in the current study, the authors sought to determine therelationship between pupil size and intensity of opiate withdrawal symptoms. To accomplish this, they examined 19 subjects meeting DSM-IV criteria for opiate dependence (304.00) on agonist therapy. All subjects were undergoing opiate detoxification with either methadone or the longer-acting 1-alpha acetylmethadol (LAMM). During two separate visits, subjects' pupil sizes were assessed in the dark using a pupillometer. At each visit, subjects completed mio standardized assessment tools (the Subjective Opiate Withdrawal Scale [SOWS] and the Weak Opiate Withdrawal Scale [WOWS]) for measuring subjective symptoms of opiate withdrawal. It was found that changes in pupil size significantly correlated with WOWS, but not with SOWS, scores. Larger pupil sizes were associated with less withdrawal distress. The sensitivity of the pupillometric test to detect increases in opiate craving during opiate agonist medication reduction was 92%, with a specificity of 57%. predictive value of a positive test was 79%, whereas the predictive value of a negative test was 80%. Pupillometry may provide an objective measure of theintensity of opiate withdrawal in subjects during gradual methadone detoxification.

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Documento generato il 05/04/20 alle ore 03:44:19