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Titolo:
EVIDENCE FOR RYANODINE RECEPTORS IN SCHISTOSOMA-MANSONI
Autore:
SILVA CLM; CUNHA VMN; MENDONCASILVA DL; NOEL F;
Indirizzi:
FED UNIV RIO DE JANEIRO,DEPT FARMACOL BASICA & CLIN,INST CIENCIAS BIOMED,ICB,CIDADE UNIV BR-21941590 RIO JANEIRO BRAZIL FED UNIV RIO DE JANEIRO,DEPT FARMACOL BASICA & CLIN,INST CIENCIAS BIOMED,ICB BR-21941590 RIO JANEIRO BRAZIL
Titolo Testata:
Biochemical pharmacology
fascicolo: 8, volume: 56, anno: 1998,
pagine: 997 - 1003
SICI:
0006-2952(1998)56:8<997:EFRRIS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+ RELEASE CHANNELS; CYCLIC ADP-RIBOSE; SMOOTH-MUSCLE; SKELETAL-MUSCLE; BINDING-SITES; ENDOGENOUS EFFECTORS; PRAZIQUANTEL; DANTROLENE; MODULATION; FIBERS;
Keywords:
RYANODINE; SCHISTOSOMA MANSONI; CALCIUM; PRAZIQUANTEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C.L.M. Silva et al., "EVIDENCE FOR RYANODINE RECEPTORS IN SCHISTOSOMA-MANSONI", Biochemical pharmacology, 56(8), 1998, pp. 997-1003

Abstract

The present study investigated the presence of ryanodine receptors inthe trematode Schistosoma mansoni. [H-3]Ryanodine specific binding sites were found in the four subcellular fractions of S. mansoni; however, more binding sites were recovered in the heterogeneous fraction P-1and the microsomal fraction P-4, as was thapsigargin-sensitive (Ca2+-Mg2+)ATPase activity, marking the sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps. This binding had an equilibrium dissociation constant (K-d) in the nanomolar range, an apparent maximal number of receptors (B-max) of about 80 fmol/mg of protein, and was modulated by ions (Ca2+, Mg2+) and some pharmacological tools such as caffeine. Ryanodine was able to accelerate the rate of Ca-45(2+) release from activelyloaded vesicles, and also to induce a transient contraction of the whole worm. We conclude that ryanodine-sensitive Ca2+ release channels are present in S: mansoni, with properties very similar to the ones present in higher animals. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:19:19