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Titolo:
EVALUATION OF DYNAMIC CHANGES IN MICROVASCULAR FLOW DURING ISCHEMIA-REPERFUSION BY MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY
Autore:
GALIUTO L; DEMARIA AN; MAYNEWMAN K; DELBALZO U; OHMORI K; BHARGAVA V; FLAIM SF; ILICETO S;
Indirizzi:
UNIV CALIF SAN DIEGO,DIV CARDIOVASC MED,200 W ARBOR DR SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DIV CARDIOVASC MED SAN DIEGO CA 92103 ALLIANCE PHARMACEUT CORP SAN DIEGO CA 92121 UNIV CAGLIARI,INST CARDIOL CAGLIARI ITALY
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 4, volume: 32, anno: 1998,
pagine: 1096 - 1101
SICI:
0735-1097(1998)32:4<1096:EODCIM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; TWO-DIMENSIONAL ECHOCARDIOGRAPHY; BLOOD-FLOW; CORONARY-OCCLUSION; CONSCIOUS DOG; INFARCT SIZE; MICROBUBBLES; PERFUSION; SALVAGE; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L. Galiuto et al., "EVALUATION OF DYNAMIC CHANGES IN MICROVASCULAR FLOW DURING ISCHEMIA-REPERFUSION BY MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY", Journal of the American College of Cardiology, 32(4), 1998, pp. 1096-1101

Abstract

Background. Dynamic changes of myocardial blood flow have been observed after reperfusion of an occluded coronary artery. MCE performed by intracoronary contrast injection can pro, ide an estimate of microvascular flow. We hypothesized that MCE performed using intravenous infusion of a new generation contrast agent and electrocardiogram gated harmonic imaging would be able to assess serial changes of microvascular perfusion. Objective. To study the potential of myocardial contrast echocardiography (RICE) to assess serial changes of microvascular flow during ischemia-reperfusion.Methods. Sixteen dogs underwent 90 or 180 min of left anterior descending coronary occlusion, followed by 180 min of reperfusion. Regional blood flow (RBF) nas measured,vith fluorescent microspheres at baseline, during coronary occlusion, and at 5, 30, 90, and 180 min during reperfusion. At the same time points, MCE was performed with intravenous infusion of AF0150 (4 mg/min). Gated end systolic images in short axis were acquired in harmonic mo de and digitized on line. Background subtracted videointensity measured from MCE and RBF obtained from fluorescent microspheres were calculated for the risk area and for a control area, and were expressed as the ratio of the two areas. Results. After initial hyperemia, a progressive reduction in flow mas observed during reperfusion. MCE correctly detected the time course of changes in flow during occlusion-reperfusion. Video-intensity ratio significantly correlated with RBF data (r = 0.79; p < 0.0001). Conclusions. The progressive reduction in blood flow occurring within the postischemic microcirculation was accurately detected by MCE. This approach has potential application in the evaluation and management of postischemic reperfusion in humans. (C) 1998 by the American College of Cardiology.

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Documento generato il 02/12/20 alle ore 05:15:33