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Titolo:
OPIOID INVOLVEMENT IN BEHAVIOR MODIFICATIONS OF MICE INFECTED WITH THE PARASITIC NEMATODE, NIPPOSTRONGYLUS-BRASILIENSIS
Autore:
PRYOR SC; CARTER C; MENDES M; CHERIAN E;
Indirizzi:
SUNY COLL OLD WESTBURY,NEUROSCI RES INST,POB 210 OLD WESTBURY NY 11568
Titolo Testata:
Life sciences (1973)
fascicolo: 18, volume: 63, anno: 1998,
pagine: 1619 - 1628
SICI:
0024-3205(1998)63:18<1619:OIIBMO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED ANALGESIA; OPEN-FIELD BEHAVIOR; SCHISTOSOMA-MANSONI; TRICHINELLA-SPIRALIS; BETA-ENDORPHIN; SYSTEM; CORTICOTROPIN; SUPPRESSION; SUBSTANCES; RESPONSES;
Keywords:
NEMATODE; NIPPOSTRONGYLUS BRASILIENSIS; BEHAVIOR; MOUSE; OPIATE; OPIOID PEPTIDE; ANALGESIA; NALOXONE; NALTRINDOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Pryor et al., "OPIOID INVOLVEMENT IN BEHAVIOR MODIFICATIONS OF MICE INFECTED WITH THE PARASITIC NEMATODE, NIPPOSTRONGYLUS-BRASILIENSIS", Life sciences (1973), 63(18), 1998, pp. 1619-1628

Abstract

Several studies have documented the opiate effects of parasitic infection on experimental animals. The current study examined the relationships between infection with the intestinal nematode, Nippostrongylus brasiliensis with analgesia and activity levels. Male white mice infected with N. brasiliensis displayed a significant increase in thermal latency thresholds that rose through the duration of infection and subsided with its termination. Analgesia first became apparent on day three-post infection but did not reach statistical significance (p < 0.05) until day 7 post infection. The maximum analgesia was reached on day 8-post infection and gradually declined. By day 15 post infection, there was no significant difference in the latency times between control and infected mice. The initial significant difference in latency roughly corresponded with the on set of egg production by the parasite. The peak difference in latency times and their subsequent decline also parallels peak egg production and the decline in egg production as the infection subsided. Both naloxone and naltrindole significantly reduced the latency times (p<0.05) of infected mice. There was also a significant difference in total ambulatory activity levels between infected and control mice. Activity levels began to decline on the second day post infection but did not reach a statistically significant difference (p < 0.05) from the controls until 9th day post infection. Infected mice that were injected with either naloxone or naltrindole had a significantly higher activity level than the infected mice injected with saline.

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Documento generato il 04/04/20 alle ore 14:53:29