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Titolo:
ENHANCED COLONIC AND RECTAL ABSORPTION OF INSULIN USING A MULTIPLE EMULSION CONTAINING EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID
Autore:
SUZUKI A; MORISHITA M; KAJITA M; TAKAYAMA K; ISOWA K; CHIBA Y; TOKIWA S; NAGAI T;
Indirizzi:
HOSHI UNIV,DEPT PHARMACEUT,SHINAGAWA KU,EBARA 2-4-41 TOKYO 1428501 JAPAN HOSHI UNIV,DEPT PHARMACEUT,SHINAGAWA KU TOKYO 1428501 JAPAN SMITHKLINE BEECHAM SEIYAKU KK,TAKASAKI RES LABS TAKASAKI GUMMA 3700072 JAPAN JAPAN BIOL CHEM CO LTD KAIZU GIFU 5030628 JAPAN NIPPON SUISAN KAISYA LTD,CENT RES LAB HACHIOJI TOKYO 1920906 JAPAN
Titolo Testata:
Journal of pharmaceutical sciences
fascicolo: 10, volume: 87, anno: 1998,
pagine: 1196 - 1202
SICI:
0022-3549(1998)87:10<1196:ECARAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN PENETRATION ENHANCERS; FATTY-ACIDS; OLEIC-ACID; STRATUM-CORNEUM; TUMOR-CELLS; RATS; GLUCOSE; PERMEABILITY; MODULATION; VESICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Suzuki et al., "ENHANCED COLONIC AND RECTAL ABSORPTION OF INSULIN USING A MULTIPLE EMULSION CONTAINING EICOSAPENTAENOIC ACID AND DOCOSAHEXAENOIC ACID", Journal of pharmaceutical sciences, 87(10), 1998, pp. 1196-1202

Abstract

The aim of this study was to test the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on insulin absorption from rat intestinal loops in situ, using a water-in-oil-in-water (W/O/W) multiple emulsion. The enhancement effect of these long-chain polyunsaturated fatty acids was compared with that of free fatty acids having a C18 alkyl chain. The emulsion (insulin dose, 50 units/kg) was administereddirectly into the colonic and rectal loops. Both EPA and DHA stronglyenhanced insulin absorption and induced hypoglycemia after colonic and rectal dosing. Comparing the pharmacological availability, the orderof effectiveness with respect to the enhanced absorption of insulin was DHA greater than or equal to EPA > C18 unsaturated fatty acids muchgreater than C18 saturated fatty acid at both sites. DHA showed greater effects upon rectal dosing than upon colonic dosing. Histological studies revealed that the emulsion incorporating DHA did not induce gross morphological changes in the structure of the intestinal mucose. Our results indicate that a W/O/W multiple emulsion incorporating DHA isa possible means of facilitating the intestinal absorption of insulinwithout inducing any serious damage to the epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:27:33