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Titolo:
MILD VENTRICULOMEGALY DETECTED IN-UTERO WITH ULTRASOUND - CLINICAL ASSOCIATIONS AND IMPLICATIONS FOR SCHIZOPHRENIA
Autore:
GILMORE JH; VANTOL J; KLIEWER MA; SILVA SG; COHEN SB; HERTZBERG BS; CHESCHEIR NC;
Indirizzi:
UNIV N CAROLINA,SCH MED,DEPT PSYCHIAT CHAPEL HILL NC 27599 DUKE UNIV,MED CTR,DEPT RADIOL DURHAM NC 27710 UNIV N CAROLINA,SCH MED,DEPT OBSTET & GYNECOL CHAPEL HILL NC 27599
Titolo Testata:
Schizophrenia research
fascicolo: 3, volume: 33, anno: 1998,
pagine: 133 - 140
SICI:
0920-9964(1998)33:3<133:MVDIWU>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTETRIC COMPLICATIONS; BRAIN ABNORMALITIES; RISK-FACTORS; SIZE; DISORDER; DISEASE; ATRIUM; FAMILY;
Keywords:
BRAIN DEVELOPMENT; HUMAN; OBSTETRIC COMPLICATIONS; FETUS; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Gilmore et al., "MILD VENTRICULOMEGALY DETECTED IN-UTERO WITH ULTRASOUND - CLINICAL ASSOCIATIONS AND IMPLICATIONS FOR SCHIZOPHRENIA", Schizophrenia research, 33(3), 1998, pp. 133-140

Abstract

The most consistent structural abnormality of the brain associated with schizophrenia is that of mild enlargement of the lateral cerebral ventricles. Mild ventriculomegaly (MVM) of the fetal brain detected in utero with ultrasound is associated with developmental delays similar to those described in children at high risk of schizophrenia. Fetal mild ventriculomegaly may be a marker for increased risk of schizophrenia and other neurodevelopmental abnormalities. Given the association between schizophrenia and obstetrical complications, pre- and perinatal complications and pregnancy outcomes were retrospectively reviewed in 51 pregnancies in which the fetus exhibited mild ventriculomegaly on routine ultrasonography and 49 control pregnancies. Mothers of childrenwith MVM were older than controls and had shorter gestations. There were no significant between-group differences in numbers of pregnancy complications or pregnancy outcomes as reflected in gestational age at birth, birthweight, or Apgar scores. Children with isolated mild ventriculomegaly tended to be male. This study indicates that isolated mildventriculomegaly detected in utero is not associated with pregnancy complications and suggests that isolated mild ventriculomegaly of the fetus is genetically determined or caused by environmental events not routinely considered pregnancy complications. (C) 1998 Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:27:49